2022年11月20日 · Overexpression of SIRT6 or SIRT7 could improve cell proliferation and protect against radiation injury in NRF2 knock-out (KO) cells by modulating oxidative-stress and DNA damage repair. Consistently, supplement of nicotinamide mononucleotide (NMN), the agonist of sirtuins, increased the level of SIRT6 and SIRT7 in NRF2 KO cells, concomitant ...

2023年11月16日 · Sirtuins被称为“长寿蛋白”，是广泛分布于细胞中的一种 去乙酰化酶 类，由一群蛋白质组成，共有7个亚型SIRT1~SIRT7。 其中，①SIRT1、SIRT6和SIRT7主要定位于细胞核。 ②SIRT2主要分布在细胞质，但部分SIRT2可转移到细胞核参与细胞周期调节。 ③SIRT3、SIRT4和SIRT5则被称为 线粒体Sirtuins，主要存在于线粒体基质中。 Sirtuins有何作用. Sirtuins的主要功能是去乙酰化蛋白质，这是一种重要的蛋白质修饰过程。 通过去乙酰化， Sirtuins可以 …

研究发现，腹腔注射NMN可显著增加肝脏、胰腺、白色脂肪组织等代谢器官NAD+含量和SIRT1活性，改善糖尿病小鼠的葡萄糖代谢。 补充试验发现， 对老年进行小鼠单核苷酸烟酰胺 (NMN)给药，可通过SIRT1依赖机制使骨骼肌线粒体功能恢复到幼龄小鼠水平。 12个月的NMN给药可减轻小鼠年龄相关的生理衰退，且无明显毒性。 基于良好的动物实验结果，NMN补充进入了一期临床试验阶段。 NR方面，在健康的中老年受试者中，进行为期6周的 口服NR 可有效提升循环血液 …

The SIRT6 activators bind, independent from substrate, to the acyl channel and might induce an enzyme conformation with increased substrate peptide affinity as suggested by such kinetic effects of free fatty acids, which are assumed to also bind to the acyl channel based on competition experiments (Feldman et al., 2013; You et al., 2017).

2024年10月10日 · Our study revealed that Sirt6 in skeletal muscles alleviates the inhibitory effect of YY1 on Dystrophin expression for NMJ maintenance. Boosting Sirt6 activity through NMN supplement can delay NMJ degeneration and improve motor functions in aged mice. Sirt6 is recognized to be involved in various physiological and pathological processes.

sirt6是两种dsb修复方法的共同上游调节因素，可以刺激nhej和hr修复。科学研究工作人员测试了来自不同物种的sirt6在刺激dsb修复过程中的活力，发现sirt6刺激nhej的能力与啮齿动物的寿命长度密切相关。

2022年10月14日 · Overexpression of SIRT6 or SIRT7 could improve cell proliferation and protect against radiation injury in NRF2 knock-out (KO) cells by modulating oxidative-stress and DNA damage repair.

2018年3月7日 · Because SIRT6 has been implicated in longevity, metabolism, DNA-repair, and inflammatory response reduction, it is an interesting target in inflammatory and metabolic diseases as well as in...

2018年9月14日 · NAM and NR are converted to nicotinamide mononucleotide (NMN) by nicotinamide phosphoribosyltransferase (NAMPT) and nicotinamide riboside kinases (NRKs), respectively. NMN is then converted to NAD + by nicotinamide

2022年11月20日 · NMN supplementation attenuated IR-induced DNA damage and intestine injury by promoting SIRT6/SIRT7 expression in the elderly model of NRF2 deficiency. NRF2 was activated upon radiation exposure, and NRF2 KO reduced the expression of sirtuins and aggravated ionizing radiation-induced DNA damage and intestinal injury.