TP53 and NMT2 - HiPPIP - severus.dbmi.pitt.edu
TP53 and NMT2. Number of citations of the paper that reports this interaction (PubMedID 16530191) 10; Data Source: HPRD (in vivo) TP53 NMT2; Description: tumor protein p53: N …
Tumor Suppressor p53: Biology, Signaling Pathways, and …
TP53 is a gene that encodes for the p53 tumor suppressor protein, commonly referred to as the “Guardian of the Genome” . Its main biological function appears to involve the protection of the …
Mutant p53 in cancer: from molecular mechanism to therapeutic ...
2022年11月18日 · TP53, a crucial tumor suppressor gene, is the most commonly mutated gene in human cancers. Aside from losing its tumor suppressor function, mutant p53 (mutp53) often …
TP53 mutations and RNA-binding protein MUSASHI-2 drive
2022年9月27日 · We identify TP53 and RNA-binding protein MUSASHI2 (MSI2) as the top-ranked sensitizer and driver of resistance to specific PRMT5i, GSK-591, respectively. TP53 deletion …
Cancer Cell：顾伟/刘彦卿等2万字长文综述全面总结p53领域研究 …
2024年5月10日 · 该综述全方位地总结了p53的发现、结构、功能、调节、在生理病理过程中的作用、作为疾病治疗靶点的潜力，以及p53研究领域的一些未解之谜。 一、p53的发现、进化与结 …
Nature Genetics：从守护者到叛徒：如何重塑失职的TP53基因？
2025年1月9日 · 在研究TP53突变的过程中，一些表面上无害的变体被发现通过破坏RNA剪接或触发无义介导的RNA降解（Nonsense-Mediated Decay, NMD），导致TP53功能丧失。 这些隐 …
N-肉豆蔻酰转移酶 2（NMT2）基因 | MCE - MCE-生物活性 ...
该基因编码两种 N-肉豆蔻酰转移酶蛋白中的一种。 N-末端豆蔻酰化是一种脂质修饰，参与调节信号蛋白的功能和定位。 编码的蛋白质催化肉豆蔻酰基添加到许多信号蛋白的 N 末端甘氨酸残 …
Targeting p53 pathways: mechanisms, structures, and advances
2023年3月1日 · Here, we provide a systematic review of the diverse molecular mechanisms of the p53 signaling pathway and how TP53 mutations impact tumor progression. We also discuss …
Pharmacological reactivation of p53 in the era of precision
2023年12月15日 · In wild-type TP53 cancer cells, p53 function is often abrogated by overexpression of the negative regulator MDM2, and agents that disrupt p53–MDM2 binding …
NMT2 - TP53 Interaction Summary | BioGRID - thebiogrid.org
BioGRID Interaction 2210742 Between NMT2 And TP53. Toggle navigation. Bio GRID 4.4