NADPH oxidase 4 is an enzyme that in humans is encoded by the NOX4 gene, and is a member of the NOX family of NADPH oxidases. [5]

2019年8月9日 · nox4 是一种跨膜蛋白，与 nox2 的同源性为 38%，但已鉴定出几种剪接变异体。 NOX4 与其他 NOX 亚型的重要区别在于，NOX4 具有组成性活性，主要产生 H2O2 而不是 O2·-。

2010年8月31日 · NAD(P)H oxidases (Noxs) produce O(2)(-) and play an important role in cardiovascular pathophysiology. The Nox4 isoform is expressed primarily in the mitochondria in cardiac myocytes. To elucidate the function of endogenous Nox4 in the heart, we generated cardiac-specific Nox4(-/-) (c-Nox4(-/-)) mice …

2024年6月6日 · 烟酰胺腺嘌呤二核苷酸磷酸氧化酶 (NOX) 是一种产生活性氧 (ROS) 的酶，最初在吞噬细胞膜中被发现。 它的主要作用是在免疫防御中，通过产生 ROS 来破坏病原体。 NOX 是一个复杂的多组分蛋白，其激活需要与其他亚基和蛋白组装。 最近对原核和真核生物 NOX 的结构研究为我们理解 NOX 调节和 ROS 产生的分子机制提供了新的视角。 这些新的信息对于人类疾病的研究具有重要意义。 作为特定的 ROS 产生酶，NOX 参与许多重要的生理过程，包括宿主防 …

2024年12月25日 · NOX4 (NADPH Oxidase 4) is a Protein Coding gene. Diseases associated with NOX4 include Ureteral Obstruction and Pulmonary Hypertension. Among its related pathways are FLT3 signaling in disease and Alzheimer's disease and miRNA effects. Gene Ontology (GO) annotations related to this gene include nucleotide binding and heme binding.

Critically, Nox4 has an unusually high K m for oxygen (∼18%), similar to the values of known oxygen-sensing enzymes, compared with a K m of 2–3% for Nox2, the phagocyte NADPH oxidase. This allows Nox4 to generate H 2 O 2 as a function of oxygen concentration throughout a physiological range of pO 2 values and to respond rapidly to changes ...

This article explores the experimental studies related to the gene, structure, physiological function and pathological significance of Nox4. As Nox4 might serve as a potential target for the therapy of cardiovascular diseases and cancer, the Nox4 inhibitor is also discussed in this article.

2023年6月23日 · Nox4, originally termed Renox, was discovered in 2000. Since that time, our understanding of its structure and function has expanded enormously. Nox4 is ubiquitously expressed and is regulated at multiple levels, including epigenetic modification, transcriptional regulation, post-translational modification and interaction with partner proteins.

烟酰胺腺嘌呤二核苷酸磷酸氧化酶4 (NOX-4)主要经介导活性氧簇 (ROS)的产生发挥生物学作用，参与自身稳态维持、炎症免疫反应、组织修复、肿瘤恶性转化等，异常NOX-4导致的氧化应激是不同肺部疾病共同的病理生理特点。 本文检索了近年来NOX-4在急性肺损伤、气道阻塞性疾病、间质性肺病、肺动脉高压和非小细胞肺癌等的文献报道，就NOX-4在不同肺部疾病中的差异调控、致病机制研究进展作一综述，以期为肺部疾病的诊治揭示新的靶点。 引用本文: 董年, 宋晨剑, 董 …

该基因编码 NOX 酶家族的一个成员，其作为 NADPH 氧化酶复合物的催化亚基发挥作用。 编码的蛋白质定位于非吞噬细胞，在那里它充当氧传感器并催化分子氧还原为各种活性氧 (ROS) 。 这种蛋白质产生的 ROS 与许多生物学功能有关，包括信号转导、细胞分化和肿瘤细胞生长。 已在 11 号染色体的另一臂上鉴定出一个假基因。 可变剪接导致多个转录变体。 [RefSeq 提供，2009 年 1 月] This gene encodes a member of the NOX-family of Enzymes that functions as the …