NPM1 is associated with nucleolar ribonucleoprotein structures and binds single-stranded and double-stranded nucleic acids, but it binds preferentially G-quadruplex forming nucleic acids. It is involved in the biogenesis of ribosomes and may assist small basic proteins in their transport to …

2024年12月25日 · NPM1 (Nucleophosmin 1) is a Protein Coding gene. Diseases associated with NPM1 include Acute Myeloid Leukaemia With Myelodysplasia-Related Features and Leukemia, Acute Myeloid. Among its related pathways are Transport of the SLBP independent Mature mRNA and Signaling by ALK fusions and activated point mutants.

The aim of this literature review is to examine the significance of the nucleophosmin 1 (NPM1) gene in acute myeloid leukaemia (AML). This will include analysis of the structure and normal cellular function of NPM1, the type of mutations commonly ...

NPM1 蛋白是一种广泛在细胞核仁表达且高度保守的磷酸化蛋白，参与核糖体蛋白的组装和运输，调控中心体的复制以及癌症抑制因子 ARF 的表达。 Hox 基因，又称同源异形基因，属于同源框家族中的一员，是生物体内一类专门调控生物形体的基因。 大多数 Hox 基因含有一段约 180 个核苷酸的同源异型盒，可以转录出含有约 60 个氨基酸序列，称为同源异形域。 “NPM1 蛋白是一个细胞核仁蛋白，但其出现 突变后能够从细胞核仁进入到细胞浆内，进而引发急性髓系白血病。 ” …

2024年12月17日 · Thanks to its property to act as histone chaperone and to shuttle between the nucleus and cytoplasm, the NPM1 protein is involved in multiple cellular function that are here extensively reviewed...

2022年8月25日 · NPM1 mutations are the most common genetic alteration in acute myeloid leukemia (AML), detected in about 30–35% of adult AML and more than 50% of AML with normal karyotype.

2022年1月13日 · Nucleophosmin (NPM1) is a multifunctional protein with both proliferative and growth-suppressive roles in the cell. In humans, NPM1 is involved in tumorigenesis via chromosomal translocations, deletions, or mutation. Acute myeloid leukemia (AML) with mutated NPM1 , a distinct diagnostic …

2021年2月4日 · Mutations of the nucleophosmin (NPM1) gene, encoding for a nucleolar multifunctional protein, occur in approximately one-third of adult acute myeloid leukemia (AML).

2022年12月9日 · 第一次系统性揭示了突变NPM1蛋白(NPM1c) 结合基因组区段通过转录劫持(transcriptional hijacking)维持HOXA基因簇基因，MEIS1基因的高表达的分子机制。 哈佛医学院Scott Armstrong课题组同时在 Cancer Discovery 发表背靠背文章揭示了相似的结论(论文题目： Mutant NPM1 directly regulates ...

2024年11月25日 · 核磷蛋白（npm1）是最丰富的核仁蛋白之一，npm1基因的突变与多种血液系统恶性肿瘤相关，包括急性髓系白血病（aml）。 有研究表明，NPM1通过促进细胞增殖和抑制细胞凋亡在多种实体瘤中发挥致癌作用。