2024年11月5日 · Regardless of time periods for MRD assessment, NPM1 qPCR provided excellent prognostic risk stratification: p=0.05 on day 0-120, p<0.0001 on day 121-240, and …

2023年1月6日 · To identify which parts of the modular NPM1 structure are responsible for delaying Aβ 42 aggregation, we designed truncated variants: NPM1 120, which contains only …

2024年12月17日 · NPM1 is the most abundant protein of the nucleolus and its restraint in such subnuclear membrane-less structure relies on both mere affinity for nucleolar components [4] …

Nucleophosmin 1 (NPM1) is also known as nucleophosmin (NPM), nucleolar phosphoprotein B23, and numatrin in mammals, and NO38 in amphibians. NPM1 was first discovered as a …

2023年11月11日 · NPM1突变AML是成人 AML 中最大的分子学亚组（30-35%），可通过分子技术和免疫组化进行识别，两者联合使用时可解决困难的诊断问题（包括识别髓系肉瘤和外显子12 …

2024年11月5日 · To evaluate its clinical relevance, we divided MRD testing into 3 different time periods after initial diagnosis (i.e., 0-120 days, 121-240 days, 240-365 days), and evaluate the …

2024年8月22日 · Recent studies have revealed various clinical applications of NPM1 mutations in AML treatment, particularly in measurable residual disease analyses that target mutant NPM1 …

2013年2月25日 · In this review, we focus on the leukemia-associated NPM1 C-terminal domain and describe its structure, function, and the effect exerted by leukemic mutations. Finally, we …

(a) NPM1 has a modular architecture, composed of a folded N-terminal pentamerization domain (NTD, residues 1-120), an intrinsically disordered region (IDR, residues 120-240) containing …

Nucleophosmin 1 (NPM1) is an abundant nucleolar protein that forms large oligomers and undergoes liquid–liquid phase separation by binding RNA or ribosomal proteins. It provides the …