Nucleolus assembly impairment leads to two-cell transcriptional ...
2023年5月18日 · Here, we demonstrate that lncRNA LoNA tethers granular-component-enriched NPM1 to dense-fibrillar-component-enriched FBL and drives the formation of …
专家点评Mol Cell | 陈玲玲组首次提出相分离促进新生成rRNA前体 …
FBL是rRNA前体加工过程中的一种重要的加工因子，包含了一个富含甘氨酸和精氨酸的内在无序区域（intrinsically disordered regions，IDRs）结构域（GAR）以及一个甲基转移酶结构 …
Phase separation-competent FBL promotes early pre-rRNA
2024年5月14日 · EGFP-tagged proteins (FBL, MD, GAR, NPM1 and PLD-MD) were cloned into pET-28a for expression in Escherichia coli BL21 (DE3) (AlpalifeBio KTSM104L), induced with …
ZNF692 regulates nucleolar morphology by interacting with NPM1 …
2023年6月21日 · In this study, we demonstrated that the nucleolar protein ZNF692 directly interacts with nucleophosmin 1 (NPM1). Knocking down ZNF692 resulted in the nucleolar …
Controlling the material properties and rRNA processing function …
2019年8月9日 · Two key nucleolar proteins that have received the most attention are nucleophosmin (B23/NPM1) and fibrillarin (FBL). NPM1 is a highly expressed nucleolar protein …
NSMB | 刘强团队揭示了长链非编码RNA介导的核仁组装调控组蛋 …
2023年5月18日，中国科学技术大学刘强团队在Nature Structural Molecular Biology杂志上在线发表了题为Nucleolus assembly impairment leads to two-cell transcriptional repression via …
NPM1 functions in epitranscriptomics - Nature Genetics
2019年9月30日 · These NPM1 mutations inhibit ribosomal RNA 2´-O-methylation by decreasing the binding of the rRNA methyltransferase FBL to small nucleolar RNAs. Thus, NPM1 …
Nuclear reorganization by NPM1-mediated phase ... - ScienceDirect
2024年8月21日 · We focused on a cellular chromatin remodeling protein, NPM1, which plays a crucial role in nucleolar formation through LLPS. NPM1 facilitates LLPS by interacting with …
核仁组装损伤通过 NPM1 介导的 PRC2 募集导致双细胞转录抑 …
Here, we demonstrate that lncRNA LoNA tethers granular-component-enriched NPM1 to dense-fibrillar-component-enriched FBL and drives the formation of compartmentalized nucleolus via …
Nucleolus assembly impairment leads to two-cell transcriptional ...
2023年5月18日 · Here, we demonstrate that lncRNA LoNA tethers granular-component-enriched NPM1 to dense-fibrillar-component-enriched FBL and drives the formation of …