NPM1 promotes nasopharyngeal carcinoma metastasis and …
This study provides the following insight; the elucidation of a novel mechanism by which NPM1 recruits Mdm2 to promote the ubiquitin-mediated degradation of p53, which results in the …
p14ARF forms meso-scale assemblies upon phase separation with NPM1 …
2024年11月11日 · Oncogenic stress induces p14 ARF to inhibit MDM2, stabilize p53 and arrest the cell cycle. Under non-stress conditions, NPM1 stabilizes p14 ARF in nucleoli, preventing …
NPM1 通过募集 Mdm2 诱导泛素化介导的 p53 降解来促进鼻咽癌 …
NPM1 promotes nasopharyngeal carcinoma metastasis and stemness by recruiting Mdm2 to induce the ubiquitination-mediated degradation of p53. Nasopharyngeal carcinoma (NPC) is …
Phosphorylated STAT5 regulates p53 expression via BRCA1/BARD1-NPM1 and MDM2
2016年12月22日 · Here we demonstrate a mutually regulatory relationship between STAT5 and NPM1. Induction of STAT5 phosphorylation at Y694 (P-STAT5) diminished NPM1 expression, …
Functions of the native NPM1 protein and its leukemic mutant
2024年12月17日 · The mammalian sirtuin SIRT7 promotes deacetylation of NPM1 that is necessary for the stress-dependent relocation of NPM1 into the nucleoplasm and MDM2 …
The role of the nucleolus in regulating the cell cycle and the DNA ...
2023年1月1日 · NPM1 and p14ARF each bind MDM2, stabilizing p53. NPM1 also activates caspase-2 via the PIDDosome. These pathways result in cell cycle arrest, senescence, or …
Nucleophosmin 1 Mutations in Acute Myeloid Leukemia - PMC
NPM1 stabilizes both TP53 and MDM2, the TP53 negative regulator, hence modulating cellular growth suppression through p53-dependent and independent mechanisms. Loss of NPM1 …
NPM1 promotes nasopharyngeal carcinoma metastasis and …
2023年5月15日 · Mechanistic analyses revealed that the E3 ubiquitin ligase Mdm2 was recruited by NPM1 to induce the ubiquitination-mediated proteasomal degradation of p53. Ultimately, …
Structural polymorphism in the N-terminal oligomerization domain of NPM1
2014年3月10日 · Our manuscript describes that the N-terminal domain of NPM1 (Npm-N) exhibits phosphorylation-dependent structural polymorphism along a broad conformational landscape …
New insights into the biology of acute myeloid leukemia with mutated NPM1
2019年1月10日 · The NPM1-MDM2 interaction is particularly enhanced upon NPM1 nuclear relocalization following nucleolar stress and this pathway is currently being investigated for the …