Germline NPM1 mutations lead to altered rRNA 2′-O ... - Nature
2019年9月30日 · We identify nucleophosmin (NPM1) as an essential regulator of 2′-O-Me on rRNA by directly binding C/D box small nucleolar RNAs, thereby modulating translation.
Self-interaction of NPM1 modulates multiple mechanisms of
2018年2月26日 · Pentameric NPM1 undergoes liquid–liquid phase separation (LLPS) via heterotypic interactions with nucleolar components, including ribosomal RNA (rRNA) and …
Functions of the native NPM1 protein and its leukemic mutant
2024年12月17日 · Within the GC, NPM1 serves as a scaffolding protein for nascent rRNA [24], helping to prevent irreversible aggregation of misfolded proteins migrating to the nucleolus …
Nucleophosmin: from structure and function to disease …
Nucleophosmin (NPM1), also known as B23, No38 or Numatrin, is an abundant nucleolar protein found in the nuclei of proliferating cells. NPM1 has been documented as participating in …
Histone Chaperone Nucleophosmin Regulates Transcription of …
2022年2月17日 · Nucleophosmin (NPM1) is a multifunctional histone chaperone that can activate acetylation-dependent transcription from chromatin templates in vitro. p300-mediated …
NPM1 Gene - GeneCards | NPM Protein | NPM Antibody
2024年12月25日 · NPM1 (Nucleophosmin 1) is a Protein Coding gene. Diseases associated with NPM1 include Acute Myeloid Leukaemia With Myelodysplasia-Related Features and …
NPM1/B23: A Multifunctional Chaperone in Ribosome Biogenesis …
2010年10月5日 · NPM1 facilitates cleavage of ribosomal RNA in vitro and acts as an endoribonuclease for the maturing rRNA transcript [13, 125]. Knockdown of NPM1 using …
The interaction between nucleophosmin/NPM1 and the large …
2021年1月1日 · NPM1 depletion inhibits the 32S pre-rRNA processing. Nucleoli are sites where both the large and small ribosomal subunits mature. Biochemical assays have suggested that …
Acetylated NPM1 localizes in the nucleoplasm and regulates ...
Acetylated NPM1 is predominantly localized in the nucleoplasm, where it associates with transcriptionally active RNA polymerase II. Deacetylation of NPM1 is brought about by human …
张笑天合作团队揭示突变NPM1蛋白在急性髓系白血病发生中分子机制|细胞|rna…
2022年12月9日 · 第一次系统性揭示了突变NPM1蛋白(NPM1c) 结合基因组区段通过转录劫持(transcriptional hijacking)维持HOXA基因簇基因，MEIS1基因的高表达的分子机制。 哈佛医学 …