摘 要：神经调节蛋白4 (neuregulin 4, NRG4)是一种含有表皮生长因子(epidermal growth factor, EGF)类似区域的蛋白分子，主要 在棕色脂肪细胞中表达和分泌。NRG4通过与EGF的受体ErbB4 (v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4)

2025年3月30日 · NRG4 (Neuregulin 4) is a Protein Coding gene. Diseases associated with NRG4 include Diabetes Mellitus and Lysosomal Storage Disease. Among its related pathways are Signaling by ERBB2 KD Mutants and Constitutive Signaling by Aberrant PI3K in Cancer.

Neuregulin 4 also known as NRG4 is a member of the neuregulin protein family which in humans is encoded by the NRG4 gene. [5][6][7] The neuregulins, including NRG4, activate erb-b2 receptor tyrosine kinase 4 (ERBB4) to initiating cell signaling through cytosolic tyrosine phosphorylation. [7]

1999年4月28日 · Here we report on a fourth neuregulin, denoted NRG-4, which acts through the ErbB-4 receptor tyrosine kinase. In addition to its novel structure, this growth factor displays a pattern of...

神经调节蛋白4（Nrg4）是一种分泌的脂肪细胞因子，在调节能量代谢系统和肥胖相关疾病的发展中发挥着重要的作用。 然而循环NRG4和代谢综合征(MetS)风险之间的联系还是未知的。

本研究证明了突变型Nrg4通过改变与受体ErbB4的结合能力，从而影响ErbB4磷酸化，改变下游STAT5/Srebp1c信号通路，影响肝内脂肪的合成。 本课题从人群遗传学数据出发，结合人群临床表现，阐明NRG4的功能增强型及功能丢失型突变参与疾病发生发展的作用机制，为NRG4的药物激动剂开发提供了直接的遗传学证据。 上海交通大学附属第六人民医院 栗扬阳，金力 为本文共同第一作者， 胡承 教授与 上海交通大学医学院附属第九人民医院 杨建军 教授为共同通讯作者。 …

Four NRG genes have been identified, each producing isoforms with specific post-translation modifications that have been demonstrated to regulate tissue morphogenesis and repair via context-specific cellular processes including proliferation, differentiation, survival, apoptosis, and …

Know comprehensive Neuregulin-4/NRG4 protein information including protein sequence, molecular weight, theoretical pI, structure, function and protein interaction.

Abstract: Neuregulin 4 (NRG4) is a novel fat secretion factor that is mainly expressed and secreted in brown fat. NRG4 specifically binds to epidermal growth factor receptor 4 (ErbB4) on hepatocyte membranes and activates downstream signaling pathways to relieve hepatic steatosis by inhibiting de novo synthesis of lipids, increasing fatty acid ...

2020年10月16日 · NRG-4 has recently emerged as an adipokine with similar potential to regulate cardiovascular responses to inflammation and injury. Beyond systolic heart failure, NRGs appear to have beneficial effects in diastolic heart failure, prevention of atherosclerosis, preventing adverse effects on diabetes on the heart and vasculature, including ...