2023年8月25日 · The evolutionary conserved NSL complex mediates transcriptional regulation of Ift genes via histone acetylations in both mouse and human cells. Depletion of the NSL complex members KANSL2 or KANSL3, or expression of the KANSL2-Δ2nd ZF mutant, results in the loss of Ift gene expression. In ciliated cells, this leads to the loss of cilia and the ...

MOF and its non‐specific lethal (NSL) complex members have been shown to localize to gene promoters and enhancers in the nucleus, as well as to microtubules and mitochondria to regulate key cellular processes.

2019年9月17日 · We analyzed the mitotic functions of four genes, Rcd1, Rcd5, MBD-R2 and wds, encoding NSL subunits. Inactivation of these genes by RNA interference (RNAi) resulted in defects in both chromosome segregation and centrosome duplication.

2020年5月7日 · Koolen-de Vries患者来源的成纤维细胞中的转录组分析揭示了由NSL复合物/ BRD4轴引起的细胞稳态信号的扰动。 我们提出，BRD4代表了NSL复合物和转录激活之间的保守桥梁，并为了解其在健康和疾病状态下的功能提供了新的视角。

In this study, Lam et al. report that the Drosophila nonspecific lethal (NSL) complex is necessary to maintain positioning of nucleosomal organization at gene promoters. Their findings show that the NSL complex establishes a canonical nucleosomal organization that enables transcription and determines TSS fidelity.

2024年4月30日 · NSL-KDD数据集是一个公开的数据集，用于网络入侵检测系统（NIDS）的研究。 它是为了解决KDD Cup 1999数据集（KDD99）中存在的一些问题而创建的，KDD99数据集存在一些标签错误和数据不平衡的问题。 以下是NSL-KDD数据集的关键特点. 1、数据集组成：NSL-KDD数据集由四个子数据集组成，分别是KDDTest+、KDDTest-21、KDDTrain+、KDDTrain+_20Percent。 其中，KDDTest-21和KDDTrain+_20Percent是KDDTrain+ …

2010年6月25日 · Here, we report the biochemical characterization of the nonspecific lethal (NSL) complex (NSL1, NSL2, NSL3, MCRS2, MBD-R2, and WDS) that associates with the histone acetyltransferase MOF in both Drosophila and mammals.

The human males absent on the first (MOF)-containing non-specific lethal (NSL) histone acetyltransferase (HAT) complex acetylates histone H4 at lysine K5, K8, and K16. This complex shares several subunits with other epigenetic regulatory enzymes, which highlights the complexity of its intracellular function.

2018年9月17日 · Here, we report that the Drosophila Non-Specific Lethal (NSL) complex is necessary to maintain this stereotypical nucleosomal organization at promoters. Upon NSL1 depletion, nucleosomes invade the NDRs at TSSs of NSL-bound genes. NSL complex member NSL3 binds to TATA-less promoters in a sequence-dependent manner.

2024年4月15日 · 本文探讨了数据质量对机器学习性能的影响，重点介绍了入侵检测领域的NSL-KDD数据集，其包含了丰富的特征和标签用于研究和比较不同的检测方法。 NSL-KDD数据集的特点、特征类型和使用方法对特征工程实践具有指导意义。 一般认为 数据质量决定了机器学习性能的上限,而 机器学习 模型和算法的优化最多 只能逼近这个上限。 因此在 数据采集 阶段需要对采集任务进行规划。在数据采集之前, 主要是从数据可用性、采集成本、特征可计算性、存储成本 …