Delineating neurotrophin-3 dependent signaling pathways …
Using a combination of pharmacology, knockout neurons and in vitro functional assays, we suggest that the NT3-TrkA complex uses Ras/MAPK and/or PI3K-AKT signaling to induce …
NT-3 promotes proprioceptive axon regeneration when …
To induce proprioceptive axon growth into the ventral horn during development, NT-3/TrkC signaling modulates the post-translational processing of SAD-A kinase (synapses of amphids …
Delineating neurotrophin-3 dependent signaling pathways
Postganglionic sympathetic neurons detect vascular derived neurotrophin 3 (NT3) via the axonally expressed receptor tyrosine kinase, TrkA, to promote chemo-attraction along intermediate …
Differential Effects of NGF and NT-3 on Embryonic Trigeminal Axon ...
2000年9月9日 · We show that in the presence of NGF, central trigeminal axons leave the tract and grow into the surrounding brainstem regions in the elongation phase without any …
Non-viral-mediated suppression of AMIGO3 promotes disinhibited NT3 ...
2018年7月16日 · We show that suppression of AMIGO3 and concomitant stimulation of DRGN with NT3 enhanced disinhibited DRGN neurite/axon regeneration and improved functional …
Role of neurotrophins in central synapse formation and ... - Nature
2002年12月1日 · For central neurons, brain-derived neurotrophic factor can increase the number of excitatory and inhibitory synapses by regulating axonal morphology or by directly promoting …
BDNF and NT-3 promote thalamocortical axon growth with
The role of neurotrophins in thalamic axon growth was studied by culturing embryonic rat thalamus on collagen-coated substrate or fixed cortical slices in the presence of either brain …
3D axon growth by exogenous electrical stimulus and soluble …
2018年1月1日 · The study investigated the effects of exogenous stimulus of electrical signals and soluble factors on axon 3D growth, and demonstrated an applied alternating EF as a robust …
Delineating neurotrophin-3 dependent signaling pathways …
2017年7月1日 · NT3 relies on activation of Ras-MAPK and PI3K (and inhibition of GSK3-beta) to promote axon growth and suppress branching. Unlike NGF, NT3 is unable to induce calcium …
Raf and Akt Mediate Distinct Aspects of Sensory Axon Growth
In this study, we analyzed the contributions of single downstream effectors of the NGF signaling pathway to axon growth of embryonic sensory neurons in vitro. We found that all effectors …
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