2011年2月18日 · We identify phosphorylation of the GLFG-repeat nucleoporin Nup98 as an important step in mitotic NPC disassembly. Mitotic hyperphosphorylation of Nup98 is accomplished by multiple kinases, including CDK1 and Neks.

2023年4月26日 · Here we directly probed conformations of the vital FG-NUP98 inside NPCs in live cells and in permeabilized cells with an intact transport machinery by using a synthetic biology-enabled...

研究结果证实，野生型核孔蛋白(wild type nucleoporin，wt-Nup)98需要脱离NPC进入细胞核核浆内，才能发挥其对有丝分裂、核浆运输等过程的调控作用；而Nup98融合基因编码的Nup98蛋白多数远离NPC，位于细胞核核浆内 [5,6,7] 。

2011年12月8日 · NUP98 is known to be fused to at least 28 different partner genes in patients with hematopoietic malignancies, including acute myeloid leukemia, chronic myeloid leukemia in blast crisis, myelodysplastic syndrome, acute lymphoblastic leukemia, …

2024年5月7日 · Here, we combine phase separation experiments and site-directed mutagenesis to gain insight into the contribution of specific FG-repeats of Nup98, an important FG-NUP of the NPC and key...

2023年2月10日 · Nup98 FG repeat domains comprise hydrophobic FG motifs linked through uncharged spacers. FG motifs capture nuclear transport receptors (NTRs) during nuclear pore complex (NPC) passage, confer...

2012年1月1日 · Together our immuno-EM data suggest that Nup98 is anchored within the center of the NPC by its C-terminal domain, whereas its N-terminal GLFG domain exhibits structural flexibility and mobility and can localize to both faces of the NPC.

Nup98, which exhibits transcription-dependent mobility at the NPC but can also bind chromatin away from the nuclear envelope, is frequently involved in chromosomal translocations in a subset of patients suffering from acute myeloid leukemia (AML).

2024年12月25日 · NUP98 (Nucleoporin 98 And 96 Precursor) is a Protein Coding gene. Diseases associated with NUP98 include Hematologic Cancer and Childhood Acute Myeloid Leukemia. Among its related pathways are Transport of the SLBP independent Mature mRNA and EML4 and NUDC in mitotic spindle formation.

2010年2月5日 · We analyzed genomic interactions of full-length nucleoporins Nup98, Nup50, and Nup62 and nucleoplasmic and NPC-tethered forms of Nup98. We found that nucleoporins predominantly interacted with transcriptionally active genes inside the nucleoplasm, in particular those involved in developmental regulation and the cell cycle.