2024年12月25日 · NACC2 (NACC Family Member 2) is a Protein Coding gene. Diseases associated with NACC2 include Congenital Mesoblastic Nephroma and Pilocytic Astrocytoma. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and DNA-binding transcription repressor activity, RNA polymerase II-specific.

启用多种功能，包括 DNA 结合转录抑制活性、RNA 聚合酶 II 特异性；组蛋白脱乙酰酶结合活性；和蛋白质同二聚化活性。 参与多个过程，包括通过负调节 RNA 聚合酶 II 启动子的转录来负调节有丝分裂细胞周期的 G1/S 转换；响应 DNA 损伤的内在凋亡信号通路的正向调节；和蛋白质同源寡聚化。 位于染色质；线粒体；和核仁。 [由基因组资源联盟提供，2022 年 4 月]

2024年1月1日 · NACC2 (NACC Family Member 2) encodes an NACC2 protein composed of 587 amino acids containing the BTB/POZ and BEN domains (Fig. 1). Similar to NACC1, NACC2 is primarily localized in the nucleus, and functions as a transcription repressor by interacting with HDAC2, which belongs to the NuRD complex.

2024年9月10日 · Here, we identify NACC2 as a novel miR-132 target implicated in both AHN and AD. miR-132 deficiency in mouse hippocampus induces Nacc2 expression and inflammatory signaling in adult NSCs. We...

2024年5月28日 · Here, we identify NACC2 as a novel miR-132 target implicated in both AHN and AD. miR-132 deficiency in mouse hippocampus induces Nacc2 expression and inflammatory signaling in adult NSCs. We show that miR-132-dependent regulation of NACC2 is involved in the initial stages of human NSC differentiation towards astrocytes and neurons.

2025年2月8日 · Gene ID: 138151, updated on 8-Feb-2025. Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; histone deacetylase binding activity; and protein homodimerization activity.

2024年6月27日 · NTRK-associated mutations often result in oncogenesis and lead to aberrant activation of downstream signaling pathways including MAPK, JAK/STAT, and PLCγ1. This study characterizes the NACC2-NTRK2 oncogenic fusion protein that leads to pilocytic astrocytoma and pediatric glioblastoma.

The protein NACC2, containing BTB and BEN domains, acts as a transcriptional regulator and induces apoptosis by sensitizing cells to DNA damage and suppressing cell proliferation [13].

2025年1月1日 · The DNA methylation level in the exon region and expression level of NACC2 in plasma could be the early biomarkers reflecting the injury of epithelial cells induced by TRAP exposure. This study goes some way to explaining why, although the respiratory system acts as a main route for inhalation of polluted air, it is the cardiovascular system ...

Chromosome 9: 138,898,383-138,987,131 reverse strand. This gene has 3 transcripts (splice variants) and 11 paralogues. A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt.