嘌呤核苷酸的从头合成途径首先要合成IMP，后者可以转化为AMP和GMP。 IMP的合成从PRPP（磷酸核糖焦磷酸）开始，共10步，先生成咪唑环，再生成次黄嘌呤。 PRPP由5-磷酸 …

2023年11月13日 · We propose an integrated model of how NAD + regulates nucleotide metabolism, with relevance to healthspan, ageing and cancer therapy. NAD +, an essential …

Inosine 5′-monophosphate dehydrogenase (IMPDH) is a purine biosynthetic enzyme that catalyzes the nicotinamide adenine dinucleotide (NAD +)-dependent oxidation of inosine …

1996年6月14日 · The IMPDH catalyzed oxidation of IMP results in transfer of hydrogen to the nicotinamide ring of NAD, forming NADH and XMP. Since direct transfer of the hydride is …

2016年11月3日 · 次黄嘌呤单核苷酸脱氢酶 (inosine 5'-mono­phosphate dehydrogenase，IMPDH) 是一种烟酰胺腺嘌呤二核苷酸 (nicotinamide adenine dinucleotide，NAD +) 依赖酶，广泛存 …

2024年11月12日 · On chromatin, IMPDH2 interacts with and modulates PARP1 activity by controlling the nuclear availability of NAD + to fine-tune the DNA damage response. However, …

IMP is the product of de novo purine nucleotide biosynthesis and the precursor to both adenine and guanine nucleotides (Scheme 1). The IMPDH-catalyzed conversion of IMP to XMP is the …

2024年12月1日 · We found that SIRT5 can directly interact with IMPDH1 and promotes desuccinylation on the N terminal of IMPDH1, thereby leading to increased IMPDH enzymatic …

2024年11月12日 · Our study identifies a non-canonical nuclear role for IMPDH2, acting as a convergence point of nuclear metabolism and DNA damage response. Oncogenic signals …

Inosine monophosphate dehydrogenase (IMPDH) catalyzes the conversion of IMP to XMP with the concomitant reduction of NAD to NADH. This reaction is the rate-limiting step in guanine …