
嘌呤核苷酸的合成代谢 - 知乎 - 知乎专栏
嘌呤核苷酸的从头合成途径首先要合成IMP,后者可以转化为AMP和GMP。 IMP的合成从PRPP(磷酸核糖焦磷酸)开始,共10步,先生成咪唑环,再生成次黄嘌呤。 PRPP由5-磷酸 …
NAD + regulates nucleotide metabolism and genomic DNA …
2023年11月13日 · We propose an integrated model of how NAD + regulates nucleotide metabolism, with relevance to healthspan, ageing and cancer therapy. NAD +, an essential …
Inosine-5′-monophosphate dehydrogenase - Wikipedia
Inosine 5′-monophosphate dehydrogenase (IMPDH) is a purine biosynthetic enzyme that catalyzes the nicotinamide adenine dinucleotide (NAD +)-dependent oxidation of inosine …
Structure and Mechanism of Inosine Monophosphate Dehydrogenase …
1996年6月14日 · The IMPDH catalyzed oxidation of IMP results in transfer of hydrogen to the nicotinamide ring of NAD, forming NADH and XMP. Since direct transfer of the hydride is …
次黄嘌呤单核苷酸脱氢酶的活性测定及临床应用
2016年11月3日 · 次黄嘌呤单核苷酸脱氢酶 (inosine 5'-monophosphate dehydrogenase,IMPDH) 是一种烟酰胺腺嘌呤二核苷酸 (nicotinamide adenine dinucleotide,NAD +) 依赖酶,广泛存 …
Nuclear IMPDH2 controls the DNA damage response by …
2024年11月12日 · On chromatin, IMPDH2 interacts with and modulates PARP1 activity by controlling the nuclear availability of NAD + to fine-tune the DNA damage response. However, …
IMP Dehydrogenase: Structure, Mechanism and Inhibition
IMP is the product of de novo purine nucleotide biosynthesis and the precursor to both adenine and guanine nucleotides (Scheme 1). The IMPDH-catalyzed conversion of IMP to XMP is the …
Desuccinylation of inosine-5′-monophosphate ... - ScienceDirect
2024年12月1日 · We found that SIRT5 can directly interact with IMPDH1 and promotes desuccinylation on the N terminal of IMPDH1, thereby leading to increased IMPDH enzymatic …
Nuclear IMPDH2 controls the DNA damage response by …
2024年11月12日 · Our study identifies a non-canonical nuclear role for IMPDH2, acting as a convergence point of nuclear metabolism and DNA damage response. Oncogenic signals …
IMP dehydrogenase: mechanism of action and inhibition
Inosine monophosphate dehydrogenase (IMPDH) catalyzes the conversion of IMP to XMP with the concomitant reduction of NAD to NADH. This reaction is the rate-limiting step in guanine …