Here, we describe for the first time, the implication of NAP-1 (Nucleosome assembly protein 1), a histone chaperone that has been involved in nuclear transport, transcription regulation, and chromatin remodeling, in telomere biology.

After controlling for patient risk factors, healthcare exposure, and antibiotic use, NAP1 was associated with severe disease (adjusted odds ratio [AOR], 1.74; 95% confidence interval [CI], 1.36-2.22), severe outcome (AOR, 1.66; 95% CI, 1.09-2.54), and death within 14 days (AOR, 2.12; 95% CI, 1.22-3.68).

Dec 25, 2024 · NAP1L1 (Nucleosome Assembly Protein 1 Like 1) is a Protein Coding gene. Diseases associated with NAP1L1 include Human Herpesvirus 8 and Chikungunya. Among its related pathways are Overlap between signal transduction pathways contributing to LMNA laminopathies and VEGFA-VEGFR2 signaling.

Oct 15, 1992 · A nucleosome assembly protein (NAP-1) of Saccharomyces cerevisiae facilitates the association of histones with DNA to form nucleosomes in vitro at physiological ionic conditions. The cloned gene was expressed in Escherichia coli using a T7 expression system, and the protein (417 amino acid residues) was purified by Mono Q column chromatography.

NRP1是拟南芥NAP1家族成员，作为组蛋白H2A-H2B的分子伴侣参与核小体移除，并能与转录因子WER结合激活下游靶基因GL2，调控植物根毛发育。 为了探索NRP1移除核小体的分子机制，本研究解析了NRP1与组蛋白H2A-H2B的复合物晶体结构（3.0 Å），发现NRP1的N端结构域可以直接结合H2A-H2B，这是NAP1家族蛋白没有被发现过的一种新的组蛋白结合方式。 遗传互补实验表明：NRP1 N端识别H2A-H2B的关键氨基酸突变的蛋白质NRP1-mN不能回复NRP缺失突变体 …

Nucleosome assembly protein 1 (NAP-1) is an integral component in the establishment, maintenance, and dynamics of eukaryotic chromatin. It shuttles histones into the nucleus, assembles nucleosomes, and promotes chromatin fluidity, …

Mar 26, 2010 · Furthermore, our studies reveal the mechanism of action of the histone chaperone nucleosome assembly protein 1 (Nap1). We present evidence for a paradigm in which nucleosome assembly requires the elimination of competing, nonnucleosomal histone-DNA interactions by Nap1.

Mar 1, 2016 · Here, we describe for the first time, the implication of NAP-1 (Nucleosome assembly protein 1), a histone chaperone that has been involved in nuclear transport, transcription regulation, and chromatin remodeling, in telomere biology.

Jan 31, 2006 · Nucleosome assembly protein 1 (NAP-1) is an integral component in the establishment, maintenance, and dynamics of eukaryotic chromatin. It shuttles histones into the nucleus, assembles nucleosomes, and promotes chromatin fluidity, thereby affecting the transcription of many genes.

Jan 13, 2025 · Nucleosome assembly protein 1 (NAP1) is a key player in chromatin dynamics, influencing DNA packaging and access within the cell nucleus. This impacts gene expression and genomic stability. Understanding NAP1’s role offers insights into biological mechanisms and potential therapeutic targets for diseases linked to chromatin misregulation.