2018年12月5日 · Based on above concept, we designed EISA precursor Npx-1P, which consisted of a NSAID drug (naproxen), a self-assembling D-peptide backbone (D-Phe-D-Phe), an enzyme trigger (D-phosphotyrosine), and a positively charged homoarginine residue at the C-terminal.

Our study shows that 1p and 2p, with the critical micelle concentrations (CMC) of about 54 and 60 μM, respectively, self-assemble to form nanoparticles, which turn into the nanofibers of Nap-wwy (1) or Nap-WWY (2) upon enzymatic dephophorylation catalyzed by alkaline phosphatase (ALP).

2017年6月19日 · In this work, we rationally designed a hydrogelator Nap-FFFYp-EDA-DOTA(Gd) (1P) which, under the catalysis of ALP, was able to self-assemble into gadolinium nanofibers to form hydrogel Gel I for enhanced T 2-weighted MR imaging of ALP activity in vitro and in tumor.

2006年1月23日 · Nucleosome assembly protein 1 (NAP-1) is an integral component in the establishment, maintenance, and dynamics of eukaryotic chromatin. It shuttles histones into the nucleus, assembles nucleosomes, and promotes chromatin fluidity, thereby affecting the transcription of many genes.

中性粒细胞碱性磷酸酶（NAP）是其胞质特殊颗粒释放的一种在碱性条件（pH9.3～9.6）能催化各种醇和酚的单磷酸酯水解的非特异性水解酶。 NAP主要存在于成熟阶段的中性粒细胞，其他成分如嗜酸、嗜碱、淋巴、单核以及巨核细胞，血小板，浆细胞等均为阴性反应。 NAP活力可反映成熟粒细胞的成熟程度和功能，随着细胞的成熟，酶的活性也逐渐增强。 当中性粒细胞活化后，NAP阳性率及积分升高。 在病理情况下，NAP活性的变化常有助于某些疾病的诊断和鉴别诊断。 可采 …

2020年6月8日 · Our work suggests that NRP proteins regulate gene expression by counteracting SWR1, thereby preventing excessive accumulation of H2A.Z. DNA encodes the genetic information in the cell, but in all...

Npx-1P, Npx-2P, Nap-1P and Npx-1 (Scheme S1) were synthesized based on reported protocols using SPPS.1 Scheme S2 shows the synthetic route of Npx-1P. The synthetic route of other compounds are the same with Npx-1P. All compounds were purified by reverse phase HPLC using HPLC grade acetonitrile and water with

Download scientific diagram | Nap-Phe-Phe-Tyr(H2PO3)-OH (1P) was synthesized with solid phase peptide synthesis (SPPS). from publication: Alkaline-phosphatase triggered self-assemblies enhances...

2017年7月5日 · Alkaline phosphatase (ALP) is an important enzyme but using ALP-instructed self-assembly of gadolinium nanofibers for enhanced T 2 -weighted magnetic resonance imaging (MRI) of tumor has not been reported. In this work, we rationally designed a hydrogelator Nap-FFFYp-EDA-DOTA(Gd) (1P) which …

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