SCN5A - Wikipedia
SCN5A is a highly conserved gene [5] located on human chromosome 3, where it spans more than 100 kb. The gene consists of 28 exons, of which exon 1 and in part exon 2 form the 5' …
Life Cycle of the Cardiac Voltage-Gated Sodium Channel NaV1.5
2020年12月16日 · Introduction. The cardiac voltage-gated sodium channel Na V 1.5 is made up of a 220-kDa pore-forming α-subunit and 30-kDa auxiliary β-subunits. For the convenience of …
Biophysical properties of NaV1.5 channels from atrial-like and ...
2023年11月24日 · Interestingly, NaV1.5 channels in atrial cardiomyocytes exhibited lower mRNA transcripts and protein expression, which could explain the lower current densities recorded by …
心脏钠通道Nav1.5翻译后修饰的研究进展 - 道客巴巴
中华心血管病杂志01年6月第49卷第6期ChinJCardiolJune01Vol.49No.6心脏钠通道Nav1.5翻译后修饰的研究进展沈利水姚焰中国医学科学院北京协和医学院国家心血管病中心阜外医院心律失 …
αB-crystallin：一新心脏钠离子通道Nav1.5作用蛋白质-学位-万方 …
Nav1.5蛋白质是形成心肌电压门控的钠通道复合体孔径最主要的α亚基，所产生的钠电流在心脏动作电位的产生以及传导过程中起到非常关键的作用。Nav1.5蛋白在体内存在于多蛋白复合体 …
The cardiac sodium channel gene SCN5A and its gene product NaV1.5…
Abstract. The gene SCN5A encodes the main cardiac sodium channel Na V 1.5. This channel predominates the cardiac sodium current, I Na, which underlies the fast upstroke of the …
The cardiac CaMKII-Nav1.5 relationship: From physiology to …
2020年2月1日 · The ideal, and perhaps eventual, synthesis between the need to solely inhibit CaMKII-mediated increases I Na,L without non-specific impairment of normal Nav1.5 or …
Roles and regulation of the cardiac sodium channel Nav1.5: …
2007年12月1日 · Abstract. During the past decade, Na v 1.5, the main voltage-gated Na + channel in the heart, has been shown to be involved in many cardiac diseases. Genetic …
Heart Rhythm 武汉大学中南医院鲁志兵教授团队揭示心脏钠离子通道Nav1.5 …
在心律失常基因治疗的研究中，由于Nav1.5蛋白较大，通常将Nav1.5的调控蛋白作为治疗靶点。因此，亟需通过基础研究寻找调节Nav1.5功能的重要作用分子，为未来靶向治疗心律失常提供新 …
Cell | 郑宁组等通过cryo-EM技术解析鼠源NaV1.5结构
2019年12月20日 · NaV1.5的结构复杂性为蛋白表达和纯化带来挑战。作者通过荧光分子筛方法筛选截短体克隆以提高蛋白表达量和样品均一性。通过膜片钳验证了截短体具有和野生型相似的 …