2003年6月27日 · Association of NCAM with GFRα1, a GPI-anchored receptor for GDNF, downregulates NCAM-mediated cell adhesion and promotes high-affinity binding of GDNF to p140 NCAM, resulting in rapid activation of cytoplasmic protein tyrosine kinases Fyn and FAK in cells lacking RET, a known GDNF signaling receptor.

Neural cell adhesion molecule (NCAM), also called CD56, is a homophilic binding glycoprotein expressed on the surface of neurons, glia and skeletal muscle. Although CD56 is often considered a marker of neural lineage commitment due to its discovery site, CD56 expression is also found in, among others, the hematopoietic system.

2017年3月27日 · The NCAM isoform with a molecular weight of 120 kDa (NCAM120) is attached to the membrane via a glycosylphosphatidylinositol anchor and is predominantly expressed by glial cells and not at the synapse. NCAM is the major carrier of an unusual carbohydrate chain, polysialic acid (PSA), which can consist of up to 200 α2,8-linked sialic acid residues.

未成熟施万细胞位于 PNS 中，显示可上调神经细胞黏附分子 (NCAM) 和胶质纤维酸性蛋白 (GFAP)。 进一步成熟后，施万细胞的髓鞘相关基因（例如髓鞘碱性蛋白 (MBP)）表达升高，以支持它们作为 PNS 运动和感觉神经元的鞘产生胶质细胞的作用。

2000年9月30日 · This study demonstrated that NCAMs could modulate LPS-stimulated NO production, most likely via interaction between NCAMs. These results suggest that neuron–glia interactions via NCAMs play an important role in regulating the activities of glial cells in the brain.

2010年5月17日 · Analysis of serial sections of perinatal Ncam−/− brain revealed that polySia-SynCAM 1 is expressed exclusively by NG2 cells, a multifunctional glia population that can receive glutamatergic input via unique neuron-NG2 cell synapses.

2009年11月23日 · The neural cell adhesion molecule, NCAM, is a key mediator of axon/dendrite growth and branching and synaptic strength and plasticity and is important in cognitive function. Through alternative splicing, three major isoforms of …

2013年1月1日 · NCAM is important in neurite outgrowth, long-term potentiation in the hippocampus and synaptic plasticity. Reduced as well as increased levels in NCAM have been linked to pathology in the brain suggesting that a shift in the equilibrium may be the key.

2015年3月10日 · Using murine glial cultures we now demonstrate that polySia-SynCAM 1 is confined to the Golgi compartment of a subset of NG2 cells and transiently recruited to the cell surface in response to depolarization. NG2 cells with Golgi-confined polySia were NCAM-negative, but positive for markers of oligodendrocyte precursor cells (OPCs).

NCAMs are a family of cell surface glycoproteins that accomplish Ca2+-independent adhesion, either through homophilic or heterophilic binding, between molecules on neighboring cells or between cell and ECM proteins. You might find these chapters and articles relevant to this topic.