2024年12月25日 · NCOA1 (Nuclear Receptor Coactivator 1) is a Protein Coding gene. Diseases associated with NCOA1 include Alstrom Syndrome and Soft Tissue Sarcoma. Among its related pathways are Epigenetic regulation by WDR5-containing histone modifying complexes and Bile acid and bile salt metabolism.

The nuclear receptor coactivator 1 (NCOA1), also called steroid receptor coactivator-1 (SRC-1), is a transcriptional coregulatory protein that contains several nuclear receptor–interacting domains and possesses intrinsic histone acetyltransferase activity.

它是 p160/类固醇受体共激活因子 (Src) 家族的成员，与其他家族成员一样具有组蛋白乙酰转移酶活性，并包含核定位信号以及 bHLH 和 PAS 结构域。 该基因的产物直接结合核受体并以激素依赖性方式刺激转录活动。 已经鉴定出编码不同亚型的选择性剪接转录物变体。 [RefSeq 提供，2008 年 7 月] The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors.

Data suggest that steroid receptor coactivators (NCOA1, NCOA2, NCOA3) are over-expressed in a number of hormone-dependent cancers where they promote tumor growth, invasion, metastasis, and chemo-resistance; with their multiple roles in cancer, steroid receptor coactivators are promising targets for development of antineoplastic agents that can ...

核受体共激活因子1 （ ncoa1 ），也称为类固醇受体共激活剂1 （ src-1 ），是一种转录核心调节蛋白，包含几个核受体与互动结构域，并具有内在的组蛋白乙酰转移酶活性。

2025年2月9日 · It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion.

2025年2月9日 · Clinical resource with information about NCOA1, Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma., and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

Nuclear receptor coactivator 1 (NCOA1) plays crucial roles in the regulation of gene expression mediated by a wide spectrum of steroid receptors such as androgen receptor (AR), estrogen receptor α (ER α), and estrogen receptor β (ER β). Therefore, ...

2024年12月27日 · NCOA1，也被称为SRC1（Steroid receptor coactivator 1），是一个关键的核受体共激活因子。 这个基因位于人类染色体2p23.3，编码一种蛋白质，属于 Basic helix-loop-helix proteins 、 Lysine acetyltransferases 和 PAS domain containing 家族。

Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; early conceptus; eye; and genitourinary system. Used to study obesity and thyroid hormone resistance syndrome. Orthologous to human NCOA1 (nuclear receptor coactivator 1).