2024年12月25日 · NCOR2 (Nuclear Receptor Corepressor 2) is a Protein Coding gene. Diseases associated with NCOR2 include Hematologic Cancer and Plasma Cell Neoplasm. Among its related pathways are Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants and Transcriptional Regulation by MECP2.

The nuclear receptor co-repressor 2 (NCOR2) is a transcriptional coregulatory protein that contains several nuclear receptor -interacting domains. In addition, NCOR2 appears to recruit histone deacetylases to DNA promoter regions.

2025年2月19日 · Title: Nuclear corepressors NCOR1/NCOR2 regulate B cell development, maintain genomic integrity and prevent transformation. Screening of organoids derived from patients with breast cancer implicates the repressor NCOR2 in cytotoxic stress response and antitumor immunity.

组蛋白脱乙酰酶 3 (HDAC3) 和核受体辅阻遏物 (NCoR1/2) 是表观遗传调节因子，在基因表达和代谢中发挥关键作用。 HDAC3 是一种 I 类组蛋白脱乙酰酶，作为转录辅阻遏物发挥作用，通过去除组蛋白和非组蛋白中的乙酰基来调节基因表达。 另一方面，NCoR1 是一种转录共阻遏物，可与核激素受体相互作用，包括过氧化物酶体增殖物激活受体 γ (PPARγ) 和肝 X 受体 (LXR)，从而调节代谢基因表达。 最近的研究揭示了 HDAC3 和 NCoR1 在代谢基因表达调节中的功能联系。 小 …

2022年10月31日 · Our studies demonstrate that NCOR1/2 play non-redundant roles in B cell development that affect STAT5, FOXO1 and p53-dependent signaling pathways, RAG gene expression, chromatin stability and B...

2019年1月21日 · Nuclear receptor corepressor 1 (NCOR1) and NCOR2 (also known as SMRT) regulate gene expression by activating histone deacetylase 3 through their deacetylase activation...

2024年4月15日 · Repression is mediated by the recruitment of nuclear receptor corepressors (NCoRs) 1 and 2 (NCoR2 is also known as silencing mediator of retinoid and thyroid (SMRT) receptors) 2.

2015年6月29日 · NCOR2 is a transcriptional corepressor that maintains the 'off state' of nonliganded nuclear receptors. Its interaction with nuclear receptors is mediated by 2 C-terminal receptor-interacting domains (RIDs).

2023年11月23日 · Screening of organoids derived from patients with breast cancer implicates the repressor NCOR2 in cytotoxic stress response and antitumor immunity. <i>NCOR2</i> is a novel candidate gene for migraine-epilepsy phenotype. Reduced NCOR2 expression accelerates androgen deprivation therapy failure in prostate cancer.

该基因编码介导某些靶基因转录沉默的核受体共阻遏物。 编码的蛋白质是甲状腺激素和视黄酸受体相关共抑制因子家族的成员。 这种蛋白质作为多亚基复合物的一部分，其中包括组蛋白脱乙酰酶以修饰染色质结构，从而阻止靶基因的基础转录活性。 该基因的异常表达与某些癌症有关。 交替剪接导致编码不同异构体的多个转录变体。 [RefSeq 提供，2011 年 4 月] This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes.