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N-亚硝基二丁胺; CAS Number: 924-16-3; EC Number: 213-101-1; Synonyms: NDBA,二丁基亚硝胺 at Sigma-Aldrich

NDBA has been used as a reference standard for the determination of the analyte in water by solid phase extraction (SPE) combined with gas chromatography-triple quadrupole mass spectrometry and in meat products by SPE combined with gas chromatography-nitrogen chemiluminescence detection (GC-NCD).

Diisobutylnitrosoamine, or NDBA, belongs to the class of molecules called nitrosamines, which interact with biological systems in very intricate ways, and are used in a variety of studies. It has the molecular formula C 8 H 18 N 2 O and two isobutyl groups bound to a …

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2021年7月6日 · 美国药典 (USP)拟定新通则<1469>NITROSAMINE IMPURITIES，用于对制药行业可能存在亚硝胺杂质进行风险评估和控制。 该标准的目的是为控制亚硝胺杂质、消除或减少亚硝胺杂质在药物产品中的存在提供一种基于科学的方法。 目前该通则已结束修订，预计今年下半年正式出版。 建议相关的原料药/制剂/辅料生厂商和供应商、合同制生产组织、药品检测和监管机构、QA/QC专家参考该通则。 USP<1469>与FDA亚硝胺杂质指南基本一致，并且都主张采用基于 …

Accurately detect and quantify trace nitrosamines (NDMA, NDEA, NEIPA, NDIPA, NDBA, etc.) in pharmaceutical drugs using our complete product portfolio and application guides for LC-MS and GC-MS. Order high-quality reference standards, columns, filters & more.

建立了9种亚硝胺类化合物（NDMA，NMEA，NDEA，NDPA，NDBA，NPiP，NPyr，NMor，NDphA）SPE-UPLC-MS的检测方法。 优化了流动相、离子源、萃取柱、样品保存条件、样品保存时间5个条件，实验结果表明：流动相使用0.1%的甲酸水和甲醇，仪器响应最好；活性炭萃取柱萃取除NDPhA的8种物质，使用大气压电离源（APCI）测定；HLB萃取柱萃取NDphA，使用电喷雾电离源（ESI）测定；样品 …

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