2024年12月25日 · NDST1 (N-Deacetylase And N-Sulfotransferase 1) is a Protein Coding gene. Diseases associated with NDST1 include Intellectual Developmental Disorder, Autosomal Recessive 46 and Autosomal Recessive Non-Syndromic Intellectual Disability. Among its related pathways are Glycosaminoglycan metabolism and Metapathway biotransformation Phase I and II.

与外泌体相比，迁移体中至少存在四种特异性蛋白，分别为N-脱乙酰酶和N-磺基转移酶1（NDST1）、EGF结构域特异性O-连接的N-乙酰氨基葡萄糖转移酶（EOGT）、磷脂酰肌醇聚糖锚生物合成类K （PIGK）和羧肽酶Q（CPQ）。 迁移体的发现丰富了细胞通讯的模式，随着研究的深入，迁移体逐渐被认为是在生物体内真实存在的一种新的“细胞器”，具有重要的生物学功能。 不少人认为迁移体是一种新的细胞信使，它们释放出的内容物可影响周围细胞的生理和病理过 …

Our data confirm NDST1 mutations as a cause of autosomal recessive intellectual disability with a distinctive phenotype, and support an important function of NDST1 in human development. Upregulation of NDST1 is associated with chemoresistance in breast cancer.

Ubiquitous expression in spleen (RPKM 12.3), lung (RPKM 12.2) and 25 other tissues. 该基因编码硫酸乙酰肝素/肝素 GlcNAc N-脱乙酰酶/N-磺基转移酶家族的成员。 编码的酶是存在于高尔基体中的 II 型跨膜蛋白。 编码的蛋白质催化硫酸盐从 3'-磷酸腺苷 5'-磷酸盐转移到硫酸乙酰肝素中氨基葡萄糖的氮。 可变剪接导致多个转录本变体。 [RefSeq 提供，2014 年 12 月] This gene encodes a member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family.

2025年2月8日 · Neuronal Ndst1 depletion accelerates prion protein clearance and slows neurodegeneration in prion infection. Overexpression of NDST1 Attenuates Fibrotic Response in Murine Adipose-Derived Stem Cells. Functional Cellular Anti-Tumor Mechanisms are Augmented by Genetic Proteoglycan Targeting.

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 is an enzyme. In humans, it is encoded by the NDST1 gene. [5][6][7] ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. ^ "Mouse PubMed Reference:".

We identified the pathogenic variants in N-deacetylase and N-sulfotransferase 1 (NDST1) and methyltransferase-like 23 (METTL23) genes segregating with the disease in an autosomal recessive manner. NDST1 encodes a bifunctional GlcNAc N-deacetylase/N-sulfotransferase with important functions in heparan sulfate biosynthesis.

2024年12月9日 · Title: MicroRNA-24 suppression of N-deacetylase/N-sulfotransferase-1 (NDST1) reduces endothelial cell responsiveness to vascular endothelial growth factor A (VEGFA). MicroRNA-191 targets N-deacetylase/N-sulfotransferase 1 and promotes cell growth in human gastric carcinoma cell line MGC803

Used to study DiGeorge syndrome; congenital diaphragmatic hernia; and newborn respiratory distress syndrome. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human NDST1 (N-deacetylase and N-sulfotransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein (s) are secreted or actually retained in intracellular locations or membrane-attached.