Nectins and Nectin-like molecules (Necl) are families of cellular adhesion molecules [1] involved in Ca 2+-independent cellular adhesion. [2] [3] Nectins are ubiquitously expressed and have adhesive roles in a wide range of tissues such as the adherens junction of epithelia or the chemical synapse of the neuronal tissue.

Nectin-4(Nectin cell adhesion molecule 4)是Nectin和Nectin样家族的细胞粘附分子，在正常的胚胎和胎儿组织中含量很高，而在成人健康组织中表达量很低。 Nectin-4是一种I型膜蛋白，二聚体Nectin-4的胞外区域由Ig V型和IgC型三个Ig域组成。

Nectins and nectin-like molecules (Necls) are immunoglobulin (Ig)-like cell adhesion molecules (CAMs) that have recently been shown to be essential contributors to the formation of cell–cell...

2024年11月5日 · Nectin-4，又称脊髓灰质炎病毒受体相关蛋白4 (PVRL4)，是由NECTIN4基因编码的一种分子质量在66kDa左右的跨膜细胞粘附分子，编码基因位于1q23.3上，属于免疫球蛋白样分子的Nectins家族。 Nectins家族共含有4个成员，Nectin-1、Nectin-2、Nectin-3和Nectin-4，均为单次跨膜蛋白，属于 Ca 2+依赖性免疫球蛋白样分子。 如图1所示，该细胞黏附分子家族具有相似的结构，（1）由三个保守的IG样环（一个IGV环和两个IGC环）组成的细胞外结构区域（2） 跨 …

A number of cell surface molecules contribute to cell-cell adhesion, and the dysfunction of adhesive processes underlies numerous developmental defects and inherited diseases. The nectins, a family of four immunoglobulin superfamily members (nectin-1 to -4), interact through their extracellular domains to support cell-cell adhesion.

We review current structural and molecular knowledge of nectin recognition processes, with a focus on the biochemical and biophysical determinants of affinity and selectivity that drive distinct nectin associations. These proteins and interactions are discussed as potential targets for immunotherapy.

2020年6月10日 · Nectin and nectin-like cell adhesion molecules (collectively referred as nectin family henceforth) are known to mediate cell-cell adhesion and related functions. While current...

Nectins and nectin-like molecules (Necls) are structurally related transmembrane proteins primarily involved in cell adhesion. Nectins and afadin, the adaptor or anchoring protein, stabilize the epithelium and endothelium and establish apical-basal polarity of epithelial cells, independently or in c …

Nectins are immunoglobulin-like cell surface molecules present on the cell surface that promotes cell-cell adhesion in a Ca2+-dependent manner. Nectins help in the synapse formation in the hippocampal region, as well as nectin dependent requirement of afadin (AF-6), which helps in spine formation [228, 229].

2012年8月19日 · Nectins are immunoglobulin superfamily glycoproteins that mediate intercellular adhesion in many vertebrate tissues. Homophilic and heterophilic interactions between nectin family members help...