2022年1月1日 · The No Expected Sensitization Induction Level (NESIL) is the point of departure for dermal quantitative riskassessment. Key steps for deriving a weight of evidence (WoE) NESIL using all available data, are presented.

“NESIL” is short for No Expected Sensitization Induction Level and is the amount of a fragrance ingredient one can be exposed to without causing skin sensitization. That begs the question: What is skin sensitization?

2012年12月1日 · Based on the concept that MEL ≫ NESIL is associated with an increased likelihood to induce skin sensitization, a strong linear association between PPD containing temporary black henna tattoos and the severity of patch test and clinical reactions has been described (Ho et al., 2005, Krasteva et al., 2010) as temporary tattoos are known to ...

2018年6月1日 · However, Quantitative Risk Assessment for fragrance ingredients requires an NESIL (no expected sensitization induction level), a dose not expected to cause induction of skin sensitization in humans. In absence of human data, this is derived from the LLNA and it remains a key challenge for risk assessors to derive this value from nonanimal data.

NESIL 预期无诱导致敏剂量 (no expected sensitizing induction level) NOAEL 未观察到有害作用的最高剂量 (no observed adverse effect level) OECD 经济合作与发展组织 (organization for economic co-operation and development) QRA 定量风险评估（ quantitative risk assessment）

2018年9月1日 · However, Quantitative Risk Assessment for fragrance ingredients requires an NESIL (no expected sensitization induction level), a dose not expected to cause induction of skin sensitization in humans. In absence of human data, this is derived from the LLNA and it remains a key challenge for risk assessors to derive this value from nonanimal data.

Sensitization assessment factors are applied to the NESIL to determine acceptable exposure levels at which no skin sensitization induction would be expected in the general population. This paper details the key steps involved in deriving a weight of evidence (WoE) NESIL for a given fragrance ingredient using all existing data, including in vivo ...

2020年12月1日 · Derivation of the NESIL: the starting point of departure for QRA2, termed the No Expected Sensitization Induction Level (NESIL) of the potential allergen (and equivalent to an induction maximum no observed adverse effect level in …

EC3经过适当换算可作为皮肤致敏定量风险评估的关键作用起始点（POD）或称为预测无皮肤致敏诱导水平（No-expected-skin-sensitization-induction-level，NESIL）。 人体试验（HRIPT，HMT）可对受试物的皮肤致敏进行验证。

However, the quantitative risk assessment for sensitizing chemicals requires a No Expected Sensitization Induction Level (NESIL), the dose not expected to induce skin sensitization in humans. We used Bayesian network integrated testing strategy (BN …