Nestin is an intermediate filament protein expressed in dividing cells during the early stages of development in the central nervous system, peripheral nervous system and in myogenic and other tissues. Upon differentiation, nestin becomes downregulated and is replaced by tissue-specific intermediate filament proteins.

巢蛋白（ Nestin ）是一种组成VI型中间纤维的蛋白质，最初作为一种神经上皮干细胞的标记蛋白得到发现 [5] ，其英语名称“Nestin”即为“neuroepithelial stem cell protein”（意为神经上皮干细胞蛋白）缩写 [6] 。

巢蛋白（Nestin）、SOX2、Notch1、HES1、HES3、E-钙粘素（E-cadherin）、闭合蛋白（occludin）。 放射状胶质细胞 波形蛋白（Vimentin）、巢蛋白（nestin）、PAX6、HES1、HES5、GFAP、GLAST、BLBP、TN-C、N-钙粘素（N-cadherin）、SOX2。

The neuroepithelial stem cell protein, or Nestin, is a cytoskeletal intermediate filament initially characterized in neural stem cells. However, current extensive evidence obtained in in vivo models and humans shows presence of Nestin+ cells with ...

2024年12月25日 · NES (Nestin) is a Protein Coding gene. Diseases associated with NES include Embryonal Carcinoma and Periventricular Leukomalacia. Among its related pathways are COPI-independent Golgi-to-ER retrograde traffic and Neural Stem Cells and Lineage-specific Markers.

Nestin is a class VI intermediate filament protein that was originally described as a neuronal stem cell marker during central nervous system (CNS) development, and is currently widely used in that capacity. Nestin is also expressed in non-neuronal immature or progenitor cells in normal tissues.

Located in cytoplasm and intermediate filament. Is expressed in several structures, including central nervous system; embryo mesenchyme; eye; foregut-midgut junction; and metanephros. Orthologous to human NES (nestin). [provided by Alliance of Genome Resources, Apr 2022]

2011年4月7日 · Neurons and glial cells in the developing brain arise from neural progenitor cells (NPCs). Nestin, an intermediate filament protein, is thought to be expressed exclusively by NPCs in the normal brain, and is replaced by the expression of proteins specific for neurons or glia in differentiated cells.

巢蛋白（nestin）是神经干细胞，胰腺干细胞的标志分子，是中间纤维家族的成员，被列为第Ⅵ类中间纤维，其结构和分子量与其他的中间纤维成员有差异。

Nestin is an intermediate filament protein that is known as a neural stem/progenitor cell marker. It is expressed in undifferentiated central nervous system (CNS) cells during development, but also in normal adult CNS and in CNS tumor cells.