The neuregulin family includes: Neuregulin 1 (NRG1), with numerous discovered isoforms stemming from alternative splicing: Type I NRG1; alternative names: Heregulin, NEU differentiation factor (NDF), or acetylcholine receptor inducing activity (ARIA) Type II NRG1; alternative name: Glial Growth Factor-2 (GGF2);

Neuregulin-1 (NRG-1), a cardioactive growth factor released from endothelial cells, is necessary for cardiac development, structural maintenance, and functional integrity of the heart.

2003年3月10日 · The neuregulins (NRGs) are cell-cell signaling proteins that are ligands for receptor tyrosine kinases of the ErbB family. The neuregulin family of genes has four members: NRG1, NRG2, NRG3, and NRG4. Relatively little is known about the biological functions of the NRG2, 3, and 4 proteins, and they a …

2008年5月14日 · Nature Reviews Neuroscience - Polymorphisms in the genes that encode neuregulin 1 (NRG1) and its receptor ErbB4 have been associated with schizophrenia. Mei and Xiong review the role of NRG1...

2024年12月25日 · NRG1 (Neuregulin 1) is a Protein Coding gene. Diseases associated with NRG1 include Schizophrenia 6 and Lung Cancer . Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Signaling by ERBB2 KD Mutants .

Neuregulin regulates glucose and lipid homeo-stasis. An engineered fusion protein using NRG-1 and Fc domain of human IgG1 (NRG1-Fc) exhibits extended half-life in circulation and improved potency in receptor signaling.

Neuregulins (NRGs) comprise a family of growth factors that activate ERBB receptor kinases. Mei and Nave review the role of Nrg-Erbb signaling in neural development, myelination, and synaptic plasticity and the possible contribution of abnormal NRG1 signaling to brain disorders.

Neuregulin 1 functions: why are there so many isoforms, and does this diversity provide insight into pathology? We face two major challenges to bridging the gap between results of human genetic studies and understanding how Nrg1–ErbB signalling contributes to psychiatric disease.

Neuregulins (NRGs) comprise a large family of EGF-like signaling molecules involved in cell-cell communication during development and disease. The neuregulin family of ligands has four members: NRG1, NRG2, NRG3, and NRG4. Relatively little is known about the biological functions of the NRG2, 3, and …

2020年6月16日 · The trophic factor Neuregulin 1 (NRG1, also called heuregulin1 or neu differentiation factor) activates signaling cascades, which regulate inhibitory neural processes important for executive ...