Neuroligin (NLGN), a type I membrane protein, is a cell adhesion protein on the postsynaptic membrane that mediates the formation and maintenance of synapses between neurons. Neuroligins act as ligands for β-neurexins, which are cell …

2008年10月15日 · Neurexins and neuroligins are synaptic cell-adhesion molecules that connect presynaptic and postsynaptic neurons at synapses, mediate signalling across the synapse, and shape the properties of...

神经连接蛋白Neuroligins (NLs)是突触后膜细胞黏附分子，其连接突触前和突触后神经元，介导突触间信号的传递，并通过特定的突触功能塑造神经网络的特性。 笔者就NLs的构成、类型、功能及应用前景等进行综述，旨在更好地认识NLs参与某些疾病的机制，并对其后续的临床治疗提供新思路。 NLs属于I类跨膜蛋白，位于突触后膜。...

Here, we review research on one major family of postsynaptic adhesion molecules, neuroligins, which bind to their presynaptic partner neurexin across the synaptic cleft. We move from a structural overview to the broad cellular and synaptic context of neuroligins, intramolecular interactions, and molecular modifications that occur within a synapse.

2022年9月10日 · Neuroligins are postsynaptic cell adhesion molecules that are relevant to many neurodevelopmental disorders. They are differentially enriched at the postsynapse and interact with their presynaptic ligands, neurexins, whose differential binding to neuroligins has been shown to regulate synaptogenesis, transmission, and other synaptic properties.

兴奋性突触后膜通过神经钙粘素 Ephrin 配体及其受体 (EphR) 与结合伴侣/细胞黏附分子 Neurexin、Neuroligin 1 和 3 之间的相互作用跨突触桥接突触前膜。 这些分子共同使突触间隙稳定，并介导神经传递。

2016年2月16日 · 大量研究表明 Neuroligin (NLG)1 对突触的发育和功能很重要，但是其内在机制尚不清楚。 已知在某些方面 NLG1 的功能不依赖突触前的 neurexin ，另外， NLG1 可以被活性依赖的蛋白水解机制裂解，产生一个胞内的 CTD 片段，但是这一过程的意义还不清楚。

2017年11月9日 · The neuroligin family cell adhesion proteins NL1, NL2, and NL3, which are expressed by cortical astrocytes, control astrocyte morphogenesis through interactions with neuronal neurexins.

Neuroligins (NLG) are a family of transmembrane adhesion proteins implicated in ASD and ID (Bourgeron, 2015). The different neuroligin isoforms are located on the autosome (NLGN1, NLGN2) and X chromosome (NLGN3, NLGN4). They differ in terms of expression localization and play a key role during development (Sudhof, 2018).

The neuroligins are cell adhesion proteins whose extracellular domain belongs to the α/β-hydrolase fold family of proteins, mainly containing enzymes and exemplified by acetylcholinesterase.