2020年7月14日 · Runx是 NVIDIA 开源的一款 深度学习实验管理工具，开源于2020年三月，是个很新的开源库。 其功能是帮助 深度学习 研究者自动执行一些常见任务，如超参数扫描、输出日志记录、运行唯一目录创建、实验总结等操作，这是考虑到深度学习一个实验就要几个小时、几天甚至几个月，如果没有及时进行保存和记录会是一件很低效的事情。 cd runx. Runx主要有三个模块，分别是runx、logx和sumx。 这些模块设计之初，期待被一起使用，但如果想只使用runx也 …

2025年1月9日 · Runx2，也被称为Runt相关转录因子2（Runt-related transcription factor 2），是一种在多种生物学过程中发挥关键作用的转录因子。作为RUNX家族的重要成员，Runx2在骨骼发育、细胞增殖以及癌症进展中扮演着举足轻重的角色。

2023年9月5日 · Our concise review on the emerging RUNX1 roles in different tissues outside the hematopoietic context provides a number of well-funded hypotheses that will open new research avenues toward a better understanding of RUNX1-mediated transcription in health and disease, contributing to novel potential diagnostic and therapeutic strategies for Down ...

2023年8月10日 · Runx cofactors compete to recruit a limited pool of Runx factors in early T progenitor cells, and a modest increase in Runx protein availability at pre-commitment stages causes premature Runx...

Databases established by next generation sequencing data analysis has identified ever increasing numbers of potential targets for RUNX proteins and other transcription factors. Here, we summarize diverse functions of RUNX proteins mainly on lymphoid lineage cells by incorporating recent discoveries.

RUNX proteins control the cellular response to DNA damage by regulating the p53, Fanconi anemia, and oxidative stress repair pathways through transcriptional or non-transcriptional mechanisms. This review highlights the importance of RUNX-dependent DNA repair regulation in human cancers.

We show that Runx1 and Runx3 function together to drive T-lineage commitment, binding the same sites. Double knockouts block both activation of T-lineage genes and repression of progenitor genes.

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2023年6月19日 · The transcription factor runt-related protein (RUNX) family is the major transcription factor responsible for the formation of osteoblasts from bone marrow mesenchymal stem cells, which are involved in bone formation. Accumulating evidence implicates the RUNX family for its role in tumor biology and cancer progression.

2015年1月1日 · We report two new RUNX1 mutations in a patient with thrombocytopenia and MDS. We demonstrate that a second hit to RUNX1 results in transformed MDS. Allogeneic transplant was successfully used to treat double RUNX1 mutant MDS.