Anti-NF186 IgG was detected by cell-based assays. Results: In 7 patients who were confirmed to have CNS involvement, the most frequent symptoms were dizziness (57%) and vision impairment (43%); lesions in centrum semiovale, cerebellum, and meninges were shown by magnetic resonance imaging (MRI).

Nerve root symmetric enlargement, T2 hyperintensity and abnormal enhancement in MRI was a prominent feature of anti‐NF155+ nodopathy. 14 In our study, brachial plexus MRI abnormality was only found in one anti‐NF186+ patient.

抗NF186抗体阳性组（12例）患者均有肢体无力，浅感觉和深感觉障碍分别有9和6例，8例为不对称性受累，仅1例出现震颤；7例行臂丛MRI，1例异常。

Objective: Nodal/paranodal autoantibodies identified a group of peripheral neuropathies independent from chronic inflammatory demyelinating polyneuropathy (CIDP). However, nodopathy with antibody against neurofascin 186 (NF186) was rarely reported. We presented a cohort of patients with anti-NF186 antibody and described the clinical profile of ...

2021年3月15日 · In the patients with biallelic Nfasc mutations and absence of full-length NF186, mild atrophy of the cerebellar vermis on MRI was observed [22]. According to the above facts, cerebellum could be one of the main targets of anti-NF186, and our study confirmed that the lesion could be detected by MRI examination.

2023年4月14日 · NF186 (green fluorescence) colocalized with anti‐NF186 antibody (red fluorescence) in P8, which indicated the presence of anti‐NF186 IgG. Nuclei of HEK cells were shown in blue fluorescence...

(A) MRI shows pontocerebellar lesion with incomplete peripheral enhancement. (B) Elevated IFNγ response against neurofascin (NF)155 and NF186 before clinical manifestation in Elispot assay.

We presented a cohort of patients with anti-NF186 antibody and described the clinical profile of the... ... plexus MRI was performed in seven anti-NF186+ patients. Only P8 showed symmetric...

针对抗NF140／186抗体阳性CIDP患者的电生理检测发现其远端复合肌肉动作电位振幅降低，病理切片显示有髓纤维大量丢失，无细胞浸润，更重要的是，腓肠神经的超微结构显示沙文细胞微绒毛消失，取而代之的是被延伸拉长的雪旺氏细胞的胞质堵塞了淋巴结间隙，这种病理改变区别于其他CIDP亚型患者，或可作为抗NF140／186抗体阳性CIDP患者的诊断标志。 CBA方法或许也可用于NF155、NF186和NF140的鉴别。 2018 Neurology测定周围神经病变患者神经筋膜蛋白抗体 …

NF186, the neuronal form of NF, localizes in the initial segment of axon and Ranvier node. NF186 antibody has been detected in demyelinating diseases of both central nervous system (CNS) and peripheral nervous system (PNS).