2015年2月17日 · During persistent antigen stimulation, CD8(+) T cells show a gradual decrease in effector function, referred to as exhaustion, which impairs responses in the setting of tumors …

2017年9月11日 · Nature Communications - NFAT nuclear translocation has been shown to be required for CD8+ T cell cytokine production in response to viral infection. Here the authors …

During persistent antigen stimulation, CD8 + T cells show a gradual decrease in effector function, referred to as exhaustion, which impairs responses in the setting of tumors and infections. …

2022年6月30日 · Zhu et al. identify Dapl1 as a negative regulator of CD8+ T cell responses by modulating NFATc2 activation and T cell exhaustion, leading to dysregulated control of chronic …

2025年3月7日 · The high mobility group (HMG)–box TF TOX imprints the T ex epigenetic landscape within 1 to 2 weeks after priming (16, 27–30).Without TOX, T ex cells cannot form …

2024年12月12日 · To examine factors downstream of TCR signaling, we focused on nuclear factor of activated T cells (NFAT), a transcription factor that orchestrates CD8 + T cell …

Here we found that NFAT5, an NFAT family transcription factor that lacks an AP-1 docking site, was highly expressed in exhausted CD8 T cells in the context of chronic infections and tumors …

我们定义了原始CD8 +中 内源性和工程NFAT1占据的基因组区域 T细胞，并显示由工程NFAT1直接诱导的基因与体内耗尽的CD8 + T细胞中表达的基因重叠。 我们的数据表明，NFAT通过与不 …

Here, we interrogated the role of two NFAT family members, NFAT1 and NFAT2, in the effector and memory phase of CD8 + T cell differentiation using LCMV Arm acute infection model. We …

2023年8月9日 · GSK3 regulates TCR-mediated NFAT activation in activated CD8 + T cells. NFAT is a crucial regulator of T-cell exhaustion, and NFAT-binding sites in genes encoding negative …