Crosstalk between NFAT and NFκB Signaling Regulates NK Cell ...
2023年11月2日 · In vitro knockout (KO) of NFAT1 (NFATc2) or NFAT2 (NFATc1) enhanced NK cell degranulation and resulted in increased production of granzyme B and perforin upon …
Involvement of NFAT Transcription Factors in NK Cell Reactivity
2016年12月2日 · When we employed NK cells with knockout (KO) of NFAT 1, 2, and 4 in comparative in vitro analyses, we surprisingly found that lack of NFAT resulted in enhanced …
Activation of the transcription factor NFAT5 in the tumor ...
2023年9月14日 · Here we found that NFAT5, an NFAT family transcription factor that lacks an AP-1 docking site, was highly expressed in exhausted CD8 + T cells in the context of chronic …
NFAT signaling is indispensable for persistent memory responses …
2024年2月12日 · To understand how NFAT signaling regulates CD8 + T cell differentiation, we performed detailed transcriptional profiling of NFATc1 KO, NFATc2 KO, NFAT DKO and WT …
NFAT 转录因子在 NK 细胞反应中的参与,Blood - X-MOL
2016年12月2日 · 通过在同基因 b16 黑色素瘤模型中使用 wt 和种系 nfat ko 动物，在体内进一步证实了 nfat 对 nk 细胞效应器功能的抑制作用，这表明 nfat ko 小鼠的转移负担显着降低。
The GPR171 pathway suppresses T cell activation and limits ... - Nature
2021年10月6日 · Blockade of GPR171 signalling by an antagonist promotes antitumor T cell immunity and improves immune checkpoint blockade therapies. Together, our study identifies …
一文搞定|活化的T细胞核内因子 (NFAT)的结构及其功能 - 知乎
活化的T细胞核内因子（Nuclear Factors of activated T cells，NFAT）是一类转录因子家族，最初是在活化的T细胞中作为一种能够结合在人白介素-2（Interleukin-2，IL-2）的启动子上的快速 …
NFAT signaling in neural development and axon growth - PMC
The NFAT (nuclear factor of activated T-cells) family of transcription factors functions as integrators of multiple signaling pathways by binding to chromatin in combination with other …
The nuclear factor of activated T cells 5 (NFAT5) contributes
2022年11月24日 · Primary IMCD cells were isolated 9,27 from an inducible NFAT5-KO mouse model (Nfat5 fl/fl-Ubc-CreERT +/−) where NFAT5 deletion is mediated by tamoxifen treatment 28.
NFAT - 百度百科
nfat 是具有多向调节功能的转录因子,如调 节t 细胞的活化,分化及自身 耐受性 等.nfat 在 多种免疫细胞均有表达,如t 细胞,b 细胞, nk 细 胞, 肥大细胞, 单核细胞 和嗜酸性粒细胞等,在机体 免疫应答 …