
NFKBIA Gene - GeneCards | IKBA Protein | IKBA Antibody
2024年12月25日 · NFKBIA (NFKB Inhibitor Alpha) is a Protein Coding gene. Diseases associated with NFKBIA include Ectodermal Dysplasia And Immunodeficiency 2 and Hypohidrotic Ectodermal Dysplasia With Immunodeficiency. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and TNFR1 Pathway.
NFKBIA gene - MedlinePlus
2013年8月1日 · The NFKBIA gene provides instructions for making one piece (the alpha subunit) of the IKK protein complex, which is a group of related proteins that regulates the activity of nuclear factor-kappa-B. Learn about this gene and related health conditions.
Targeting NF-κB pathway for the therapy of diseases: mechanism and ...
2020年9月21日 · Emerging studies indicate that dysregulated NF-κB activity causes inflammation-related diseases as well as cancers, and NF-κB has been long proposed as the potential target for therapy of...
Nuclear factor-kappa-B-inhibitor alpha (NFKBIA) is a ... - PubMed
Our findings represent the first characterization of NFKBIA and IκBα as maternal effectors in both the bovine oocyte and embryo. We suggest a role for NFKBIA as a marker of NF-κB/p65 activation in the human oocyte and early embryo.
NFKBIA NFKB inhibitor alpha - NIH Genetic Testing Registry …
2024年12月10日 · Phosphorylated IκBα predicts poor prognosis in activated B-cell lymphoma and its inhibition with thymoquinone induces apoptosis via ROS release. Hussain AR, Uddin S, Ahmed M, Al-Dayel F, Bavi PP, Al-Kuraya KSHussain AR, et al. PLoS One, 2013. PMID 23555990. Silenced expression of NFKBIA in lung adenocarcinoma patients with a never-smoking history.
NFKBIA NFKB inhibitor alpha [ Homo sapiens (human) ]
2025年2月20日 · HIV-1 Tat upregulates the expression of nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (NFKBIA, IkappaB alpha) in human primary T cells PubMed tat
The NFKBIA gene and its putative association with human ageing
2023年8月28日 · Transgenic mice expressing dominant-negative IkB, and exhibiting functional inhibition of NF-kB signaling in endothelial cells, were protected from age-related insulin resistance and vascular senescence and, displayed a prolonged lifespan.
4792 - Gene ResultNFKBIA NFKB inhibitor alpha [ (human)]
Gene ID: 4792, updated on 9-Feb-2025. This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses.
Entry - *164008 - NUCLEAR FACTOR KAPPA-B INHIBITOR, ALPHA; NFKBIA …
The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB, 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm.
Nuclear factor-kappa-B-inhibitor alpha (NFKBIA) is a …
2011年2月26日 · Here, we focus on nuclear factor (NF)-κB, a TF involved in several cellular processes, studying NFκB - inhibitor (NFKBIA) mRNA and its protein product, IκBα, during OET. NFKBIA and IκBα are part of a regulatory loop, as IκBα is the major down-regulator of NF-κB activation while NFKBIA transcription is activated by NF-κB.
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