2024年12月25日 · NFKBIA (NFKB Inhibitor Alpha) is a Protein Coding gene. Diseases associated with NFKBIA include Ectodermal Dysplasia And Immunodeficiency 2 and Hypohidrotic Ectodermal Dysplasia With Immunodeficiency. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and TNFR1 Pathway.

2013年8月1日 · The NFKBIA gene provides instructions for making one piece (the alpha subunit) of the IKK protein complex, which is a group of related proteins that regulates the activity of nuclear factor-kappa-B. Learn about this gene and related health conditions.

2020年9月21日 · Emerging studies indicate that dysregulated NF-κB activity causes inflammation-related diseases as well as cancers, and NF-κB has been long proposed as the potential target for therapy of...

Our findings represent the first characterization of NFKBIA and IκBα as maternal effectors in both the bovine oocyte and embryo. We suggest a role for NFKBIA as a marker of NF-κB/p65 activation in the human oocyte and early embryo.

2024年12月10日 · Phosphorylated IκBα predicts poor prognosis in activated B-cell lymphoma and its inhibition with thymoquinone induces apoptosis via ROS release. Hussain AR, Uddin S, Ahmed M, Al-Dayel F, Bavi PP, Al-Kuraya KSHussain AR, et al. PLoS One, 2013. PMID 23555990. Silenced expression of NFKBIA in lung adenocarcinoma patients with a never-smoking history.

2025年2月20日 · HIV-1 Tat upregulates the expression of nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (NFKBIA, IkappaB alpha) in human primary T cells PubMed tat

2023年8月28日 · Transgenic mice expressing dominant-negative IkB, and exhibiting functional inhibition of NF-kB signaling in endothelial cells, were protected from age-related insulin resistance and vascular senescence and, displayed a prolonged lifespan.

Gene ID: 4792, updated on 9-Feb-2025. This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses.

The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB, 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm.

2011年2月26日 · Here, we focus on nuclear factor (NF)-κB, a TF involved in several cellular processes, studying NFκB - inhibitor (NFKBIA) mRNA and its protein product, IκBα, during OET. NFKBIA and IκBα are part of a regulatory loop, as IκBα is the major down-regulator of NF-κB activation while NFKBIA transcription is activated by NF-κB.