Neutrophil gelatinase-associated lipocalin (NGAL) is an emerging biomarker for the early detection of AKI. Studies have shown NGAL to be a highly induced protein in the kidney after ischemic or nephrotoxic injury.

Urinary neutrophil gelatinase-associated lipocalin (NGAL) has shown promise in differentiating acute tubular necrosis (ATN) from other types of acute kidney injuries (AKIs) in cirrhosis, particularly hepatorenal syndrome (HRS).

2024年6月7日 · The NGAL Test is a particle-enhanced turbidimetric immunoassay for the quantitative determination of NGAL in human urine and plasma on automated clinical chemistry analyzers. NGAL measurements are useful in the risk assesment of AKI.

2023年12月7日 · The neutrophil gelatinase-associated lipocalin (NGAL) test, also known as the ProNephro AKI test, is designed to help doctors identify patients at risk for developing or having moderate to severe AKI within 48-72 hours in the intensive care setting.

NGAL is produced in the distal nephron and its synthesis is up-regulated in response to kidney injury. NGAL is an ion-transporting agent. Markers of damage are potentially better than functional markers. NGAL is also a powerful marker of kidney disease progression.

The Neutrophil Gelatinase-Associated Lipocalin (NGAL) test is a powerful diagnostic tool for identifying kidney problems early, often before symptoms develop. By measuring NGAL levels in blood or urine, this test helps detect acute kidney injury and chronic kidney disease, enabling timely intervention and improved outcomes.

2019年4月25日 · Neutrophil gelatinase-associated lipocalin (NGAL) is an emerging biomarker for earlier identification of acute kidney injury (AKI). Using similar methodology, a reference interval for urine NGAL in adults was determined to be <113 ng/mL. Age- and sex-specific ranges have not been established, but there is evidence that urine NGAL concentrations ...

Neutrophil gelatinase-associated lipocalin (NGAL), a 25 kDa protein produced by injured nephron epithelia, is one of the most promising new markers of renal epithelial injury. In contrast to serum creatinine and urinary output, which are measures of ...

2025年1月3日 · Neutrophil gelatinase-associated lipocalin (NGAL) is a 25-kDa protein produced and secreted by injured kidney tubule epithelial cells, and can serve as an early urinary biomarker for AKI. ProNephro AKI (NGAL) is an immunoassay for the quantitative determination of NGAL in urine (uNGAL) that recently received FDA clearance.

2024年11月2日 · Neutrophil gelatinase-associated lipocalin (NGAL) has been identified as the most promising biomarker for predicting acute kidney injury due to upregulation as early as 2 h before kidney injury. Methods: Urine samples from 52 adult subjects were utilized to evaluate the accuracy of acute kidney injury diagnosis using the XpressCard for human NGAL.