Relative to $\ce {OH^-}$, the greater amount of solvation of $\ce {NH2^-}$ increases the activation energy required to initiate the subsitution reaction since solvation can be said to bring down the energy of the reactant in the reaction energy profile.

2024年1月17日 · This article explains the question of what is OH- and if it is a strong nucleophile along with NH₂. What is OH? Hydroxide, hydroxide ions, hydroxyl radicals, and or simply OH −, is the chemical term for this diatomic which is made up of an oxygen atom and a hydrogen atom bound together by a covalent connection. There is an electric charge ...

2018年5月17日 · Why is -NH2 a stronger base than -OH? The easier way to think about it is why -NH3+ is more stable than -OH2+. Nitrogen is more able to part of a positively charged system than oxygen, thus, it’s easier to form the protonated …

2023年7月4日 · N H 2 - and OH- are both nucleophiles, which are species that donate a pair of electrons to form a new chemical bond. However, N H 2 - is generally a stronger nucleophile than OH-. The strength of a nucleophile depends on several factors, including its basicity and the availability of its lone pair of electrons.

2020年3月23日 · Mesomeric effect follows the order: NH2>OH>OR. Lone pair of electrons are more stable on O atom than N atom since O is more electronegative than N. OH>OR due to Bent's Rule.

2022年9月8日 · - The NH2 group has the highest priority, because N has a higher atomic number than either C or H—designate the amino group "a" - The H has the lowest

羟基相对氨基来说是质子供体，而对羧基来说却是质子受体，因此简单比较式有问题的，且与氨基或羧基相连基团的大小也是重要的影响因素。 要理解他们的相对作用强度可以：将具体酸和胺生成的盐溶于醇中测定pH值，如为酸性则羧基与羟基作用强，碱性则相反。 羟基相对氨基来说是质子供体，而对羧基来说却是质子受体，因此简单比较式有问题的，且与氨基或羧基相连基团的大小也是重要的影响因素。 要理解他们的相对作用强度可以：将具体酸和胺生成的盐溶于醇中测 …

2023年6月20日 · O is more electronegative than N. The stronger polarity outcompetes the additional H-bond that the amine provides. I am a little vary about this, it said the hydroxyl compound has stronger H bonds than the amine compound. While on an individual level, I …

2009年8月25日 · Amides (RCOO-NH2) are the strongest base in the CA derivs, more so than (RCOO-OH, obviously since that is carbolxylic acid). But rather than looking at electronegativity (which refers to electrons in a bond), ionize your species and examine the leaving group.

氯胺NH2Cl之类能与其反应. 2。 氨基与吸电子基团例如Tos,BoC,Ts,甚至酰胺的胺都有可能和羟基发生mitsunobu反应. 伯胺和醇可以反应生成仲胺。 不知道你具体的底物是什么. ROH …