CD38靶点简介：具有免疫抑制作用的特异性蛋白 - 知乎
CD38（Cluster of Differentiation 38）于1980年被科学家E.L. Reinherz和S.F. Schlossman等人发现。 当时的研究认为CD38是T细胞激活的特异性marker，而对其生物学功能则没有进行过多 …
CD38 knockout natural killer cells expressing an affinity optimized ...
2022年2月1日 · There is a strong biological rationale for the augmentation of allogeneic natural killer (NK) cell therapies with a chimeric antigen receptor (CAR) to enhance acute myeloid …
CD38 deletion of human primary NK cells eliminates …
2020年11月19日 · We used the CRISPR/Cas9 system to delete CD38 (CD38KO) in ex vivo expanded peripheral blood NK cells. These CD38KO NK cells were completely resistant to …
有趣的“死循环”，CD38靶点开发策略的“烧脑”生态圈 - 知乎
研究发现敲除CD38的NK细胞可以有效的消除Daratumumab介导的NK细胞的残杀并且增强NK细胞的功能，这种增强在一定程度上依赖于CD38敲除后的代谢重编程。 既然NK细胞敲除CD38之 …
Epigenetic regulation of CD38/CD48 by KDM6A mediates NK cell …
2024年2月14日 · In summary, our data reveal a molecular mechanism whereby KDM6A mediates ADCC not only through regulating CD38 but also by modulating NK activity through CD48 …
CD38 敲除原代 NK 细胞以防止“自相残杀”并提高 Daratumumab
为了检查 cd38ko-nk 细胞的功能状态，我们使用了 6 个具有不同 cd38 表达水平的 mm 细胞系（lp-1、rpmi8226、h929、mm.1s、opm-2、和 kms-11) 以及从新诊断或复发患者的骨髓中分离的 …
Roles of CD38 in the Immune Response to Infection - PMC
CD38 is a multifunctional transmembrane protein that is widely expressed in immune cells. In lymphocytes, monocytes, macrophages, dendritic cells, granulocytes, and natural killer (NK) …
CD38-CAR human NK cells in combination with ATRA
2024年12月1日 · CD38-CAR NK and T cells showed enhanced killing toward CD38-expressing hematologic malignancies. ATRA upregulates CD38, enhancing the activity of CD38-CAR NK …
Nicotinamide-Expanded Allogeneic Natural Killer Cells with CD38 ...
2023年12月7日 · We have developed genetically engineered NK cells tailored to treat MM, in which CD38 was knocked-out using CRISPR-Cas9 technology and an enhanced chimeric …
CD38 expression and function in NK cells. (A) Role of CD38 in …
NK cells constitutively express CD38 molecule [50], while CD38 + T lymphocytes are considered activated [51]. Earlier, we have shown both CD56 − and CD56 + T cells had the highest levels …