CD16 plays a significant role in early activation of natural killer (NK) cells following vaccination. In addition, CD16 downregulation represents a possible way to moderate NK cell responses and maintain immune homeostasis in both T cell and antibody-dependent signaling pathways. [10]

Activated NK cells loose CD16 (FcRγIII) and CD62L through a metalloprotease called ADAM17. Inhibition of ADAM17 enhances CD16 mediated NK cell function by preserving CD16 on the NK cell surface to enhance ADCC.

2023年2月13日 · nk细胞可通过cd16受体介导的adcc，杀死igg1或igg3抗体靶向的细胞。nk细胞表面cd16的不同形态，会影响cd16与抗体fc端的亲和力。 具体来说，cd16蛋白第158位的氨基酸为苯丙氨酸（158f）时，与fc的亲和力低，而这一位置上的氨基酸为缬氨酸（158v）时，与fc的亲和力 …

2013年5月2日 · The Fc receptor CD16 is present on essentially all CD56(dim) peripheral blood natural killer (NK) cells. Upon recognition of antibody-coated cells it delivers a potent signal to NK cells, which eliminate targets through direct killing and cytokine production. Here we investigated the regulation of CD16 surface expression after NK cell activation.

2024年4月4日 · Improving the NK cell response, either through enhancing NK cell responses or identifying features of NK cells with superior cytotoxic potential, is widely expected to improve treatment...

2023年6月11日 · CD16 (Fcγ receptor III) is a receptor expressed on NK cells that facilitates antibody-dependent cellular cytotoxicity (ADCC) by binding to the Fc portion of various antibodies. The enhancement...

2016年9月27日 · CD16, the FcγRIIIA, is essential for ADCC by NK cells, and is also expressed by a subset of human blood monocytes. We found that human CD16− expressing monocytes have a broad spectrum of ADCC...

2022年9月26日 · 根据CD16、CD56表达的差异，可以将NK细胞分为两大亚型：CD56 dim CD16 + NK和CD56 bright CD16-NK。 CD56 bright NK - 细胞是强有力的细胞因子产生者，但缺乏CD16a；而CD56 dim CD16 + 具有高度的细胞毒性，能表达CD16a[1]。

2025年3月8日 · Zhang等通过增强CD16信号通路，使CAR-NK细胞同时靶向CD33和B16，提高了细胞毒性四倍，同时保持良好的安全性。 CD123 Morgan等通过基因工程改造NK细胞，使其持续产生IL-15并表达抗CD123 CAR，显著延长了NK细胞的存活时间并增强了抗白血病效果。

2021年5月20日 · Natural killer (NK) cells hold a pivotal role in tumor-targeting monoclonal antibody (mAb)-based activity due to the expression of CD16, the low-affinity receptor for IgG. Indeed, beyond exerting cytotoxic function, activated NK cells also produce an array of cytokines and chemokines, through which …