CD49a Targeting Enhances NK Cell Function and Antitumor …
2025年1月9日 · Blockade of CD49a using an mAb suppressed tumor development in mice, and combination treatment with anti-PD-L1 further enhanced antitumor efficacy. Our research reveals CD49a on NK cells as an immunotherapeutic target and highlights the potential clinical applications of CD49a-targeted therapies.
CD49a+CD49b+ NK cells induced by viral infection reflect an
Adoptive transfer experiments revealed that cNK cells could convert into CD49a + CD49b + NK cells following viral infection. Collectively, these results suggest that viral infection-induced CD49a + CD49b + NK cells represent a transiently activated state of cNK cells.
IFN-γ induces aberrant CD49b+ NK cell recruitment through
2014年11月6日 · We demonstrated herein that IFN- γ induced a highly increased proportion of CD49b + NK cells in the uterus and peripheral blood and it induced a significantly upregulated uterine expression of...
病毒感染诱导的CD49a + CD49b + NK细胞反映了常规NK细胞的活 …
天然杀伤（nk）细胞是重要的先天效应物，在防御肿瘤和感染中起关键作用，并参与调节适应性免疫。最近的研究揭示了nk细胞的表型和功能异质性。
Cutting Edge: Identification and Characterization of Human …
2015年3月15日 · Human intrahepatic CD49a + NK cells express killer cell Ig-like receptor and NKG2C, indicative of having undergone clonal-like expansion, are CD56 bright, and express low levels of CD16, CD57, and perforin. After stimulation, CD49a + NK cells express high levels of inflammatory cytokines but degranulate poorly.
Human-Induced CD49a + NK Cells Promote Fetal Growth - PubMed
2022年2月4日 · CD49a + natural killer (NK) cells play a critical role in promoting fetal development and maintaining immune tolerance at the maternal-fetal interface during the early stages of pregnancy. However, given their residency in human tissue, thorough studies and clinical applications are difficult to perform.
Measurement of four novel endometrial NK cell subsets by …
3 天之前 · During the window of implantation (WOI), the proportion of endometrial natural killer cells increases dramatically, rising from 30% in the proliferative phase to 70% (Kanter et al., 2021), making them the predominant immune cell population.The substantial increase in endometrial NK cells is likely involved in key processes of endometrial preparation and embryo implantation, including ...
细胞因子定向诱导CD49a~+ EOMES~(-/+) NK细胞的发育 - 百度学术
研究背景:NK细胞是一类固有免疫细胞,其可以通过细胞杀伤和分泌炎性因子的作用来控制病毒感染和肿瘤进程.传统NK细胞(conventional NK(cNK)cells)参与全身循环,其表达CD49b和核心转录因子EOMES.而组织居留NK细胞(tissue-resident NK(trNK)cells)则定居在特定的组织中,高表达CD49a和 ...
Accumulation of Tumor-Infiltrating CD49a + NK Cells Correlates …
2019年9月3日 · Our findings show that CD49a + NK cells accumulate in liver tumor and suggest a role for CD49a + NK cells in the negative regulation of immune responses and the development of HCC.
Human-Induced CD49a + NK Cells Promote Fetal Growth
2022年2月4日 · Our group found that uterine NK cells (uNKs) in humans have a large amount of CD49a + trNK cells, specifically, CD49a + Eomes + uterine trNK cells, which comprise 85% of all NK cells from normal human decidua during the first trimester, secrete growth-promoting factors, and enhance fetal growth during the critical early stages of fetal ...