Interleukin-21 engineering enhances NK cell activity against ...
2024年8月12日 · Shanley et al. engineer NK cells to express interleukin (IL)-21, which show superior safety and long-term anti-tumor activity compared to IL-15 NK cells. Key transcription …
Membrane bound IL-21 based NK cell feeder cells drive robust
2019年10月17日 · We created an NK cell feeder cell line termed ‘NKF’ through overexpressing membrane bound IL-21 that is capable of inducing robust and sustained proliferation (>10,000 …
IL-21R-STAT3 signalling initiates a differentiation program in
2023年11月4日 · Mechanistically, an IL-21R-STAT3 axis is essential for initiating the trNK cell differentiation. The fully differentiated trNK cells demonstrate enhanced functionality, which is …
Sequential Exposure to IL21 and IL15 During Human Natural Killer …
2023年11月1日 · Our findings define the impact of mbIL15 versus mbIL21 during NK expansion and reveal a previously underappreciated tradeoff between NK yield and function for which …
Highly efficient IL-21 and feeder cell-driven
Natural killer (NK) cells are promising antitumor effector cells, but the generation of sufficient NK cell numbers for adoptive immunotherapy remains challenging. Therefore, we developed a …
IL-21 Limits NK Cell Responses and Promotes Antigen ... - Cell …
2001年11月2日 · By blocking responsiveness of NK cells to the growth-promoting effects of IL-15 while acting as a potent IFNγ inducer, IL-21 may be a key regulator of NK cell functional status …
IL-21-mediated reversal of NK cell exhaustion facilitates anti …
2017年6月6日 · IL-21 promotes the maturation of NK cell progenitors and activates the anti-tumour effects of NK cells through the NKG2D pathway 16, 17. In addition, IL-21 activates …
Interleukin-21 engineering enhances NK cell activity against ...
2024年8月12日 · We compared the anti-GBM activity of NK cells engineered to express interleukin (IL)-15 or IL-21. Using multiple in vivo models, IL-21 NK cells were superior to IL-15 …
Multiple effects of IL-21 on human NK cells in ex vivo expansion
The present study aims to assess the effects of membrane-bound and soluble IL-21 on primary human NK cells during ex vivo expansion. IL-21 was found to have multiple effects on NK …
Membrane-bound IL-21 promotes sustained ex vivo proliferation ... - PubMed
We developed K562-based aAPCs with membrane-bound IL-21 (mbIL21) and assessed their ability to support human NK-cell proliferation. In contrast to mbIL15, mbIL21-expressing …