2024年12月25日 · NLRP2 (NLR Family Pyrin Domain Containing 2) is a Protein Coding gene. Diseases associated with NLRP2 include Oocyte/Zygote/Embryo Maturation Arrest 18 and Fanconi Anemia, Complementation Group D1. Among its related pathways is Nucleotide-binding oligomerization domain (NOD) pathway.

2023年9月22日 · In this review, we discuss recent advances in NLRP2 signalling research and investigate the potential roles of NLRP2 in the pathogenesis of various disorders, which may contribute to the development of novel strategies for prevention and/or treatment of diseases.

2024年4月22日 · Here, we provide the latest research progress on NLRP inflammasomes, including NLRP1, CARD8, NLRP3, NLRP6, NLRP7, NLRP2, NLRP9, NLRP10, and NLRP12 regarding their structural and assembling features, signaling transduction and …

NLRP2 gene is one of the NLR family; it is believed to contribute to the regulation of immune responses (Minkiewicz, de Rivero Vaccari and Keane 1121). Although it is not well understood, the NLRP2 gene is responsible for maintaining fertility in …

2014年5月29日 · In this study, we consider a functional role for the NLRP2 -related, higher primate-specific, processed pseudogene NLRP2P, which is closely related to Pyrin-only protein 2 (POP2/PYDC2), a...

NLRP2 is a regulator of NF-κB signaling and its functional expression is necessary for fertility, healthy maternal/fetal relationships, and embryo development (Fontalba et al., 2007).

NLRP2P is located on chromosome X (distant from NLRP2 and NLRP7 on chromosome 19), contains a discernable poly-(A) tract near the remnants of the 3’ end of the NLRP2/7-related sequence, lacks NLRP2/7 introns, and has multiple stop codons.

2023年9月22日 · Here, we highlight the most current progress on NLRP2 in inflammasome activation, effector function and regulation of nuclear factor-κB. And we discuss functions of NLRP2 in inflammatory diseases, reproductive disorders and the potential implication of NLRP2 in human diseases.

NLRP2 is poorly understood, these results indicated that NLRP2 might form the inflammasome and play a role in host defence and inflammation. In addition, studies have shown that NLRP2 mediates activation of the NLRP3 inflammasome. Treatment of Mono-Mac-6 cells with Porphyromonas gingivalis leads to upregulation of NLRP3 and IL-1β and ...

Gain- and loss-of-function studies revealed that NLRP2 silencing promoted cell proliferation and migration by stimulating NF-kB signaling in the microenvironment, which induced epithelial-to-mesenchymal transition (EMT) phenotype and cytoskeleton reorganization in LUAD cells.