2012年4月1日 · Three lines of evidence demonstrate the anti-metastatic activity of NM23: first, overexpression of NM23 in metastatic cell lines reduces their metastatic potential in xenograft …

Metastasis suppressor genes (MSGs) inhibit different biological processes during metastatic progression without globally influencing development of the primary tumor. The first MSG, …

Group I NM23 genes encode enzymes with evolutionarily highly conserved nucleoside diphosphate kinase (NDPK) activity. In this review we summarize how results from NDPKs in …

2021年3月22日 · Non-metastatic protein 23 H1 (Nm23-H1), a housekeeping enzyme, is a nucleoside diphosphate kinase-A (NDPK-A). It was the first identified metastasis suppressor …

In this light, further understanding of Lamins/TRF1/2/NM23-H2 or FEN1/NM23-H2 associations might provide meaningful insights into the role of NM23 proteins in telomere biology. Finally, …

2021年3月1日 · This review summarized and discussed the regulatory mechanisms of NM23-H1 in cancer including transcriptional activation, subcellular location, enzymatic activity, and …

2020年3月18日 · The metastasis suppressor gene NME/nm23/NDPK was discovered in 1988 by Steeg et al, 1 from the analysis of murine melanoma K-1735 cells based on its differential …

NM23 is the first discovered metastasis suppressor gene, which does not affect the growth of primary tumor but a powerful inhibitor of metastases of tumors. Altered NM23 expression was …

2006年6月1日 · The protein product of nm23-H1 gene has activity of nucleoside diphosphate (NDP) kinase, which catalyzes the phosphorylation of nucleoside diphosphates to the …

2017年1月1日 · The nm23 gene was discovered using differential colony hybridization between low and high tumor metastatic potential K-1735 murine melanoma cell lines. Nm23 mRNA and …