2025年1月26日 · The results revealed that intestinal tight proteins, including ZO-1 and Occludin, were significantly reduced in HFD-fed mice but markedly restored after nobiletin intervention, particularly in NOH mice.

2012年6月11日 · To study how T regs specifically suppress auto-Ab production against peripheral tissue antigens, we used transgenic mice expressing a membrane-bound fusion protein of OVA and HEL under the control of the nephrin promoter in kidney podocytes (NOH mice) .

Human Microglia Extensively Reconstitute in Humanized-BLT Mice With Human Interleukin-34 Transgene and Support HIV-1 Brain Infection. Humanized bone marrow-liver-thymic mouse (hu-BLT mouse), macroglia, HIV-1, central nervous system (CNS),

2024年7月3日 · NOH mice (red) develop significant proteinuria after OT-1 cell transfer and infection, compared to wt mice (blue) and NOH mice after either infection (green) or OT-1 transfer (yellow).

2009年4月20日 · Repetitive OT cell injection causes functional and structural kidney damage in NOH mice. NOH mice were injected with 5 × 10 6 OT-I cells and with 5 × 10 6 activated OT-II cells on days 0, 7, 14, and 21.

Histology of NOH mice after OVA/Alum immunization and T cell transfer. NOH and wt mice 6 were injected with 5x10 OT-I and OT-II cells as indicated. Mice were immunized with OVA/Alum using μ g 1:1...

Download scientific diagram | Generation and characterization of NOH mice. (A) Construct used for the generation of NOH mice. (B) Immunohistochemical staining of a glomerulus from a NOH...

Download scientific diagram | Ovalbumin expression in parietal cells of NOH mice. ( A ) Immunohistochemical staining of a 6 6 glomerulus from a NOH mouse on d7 after adoptive transfer of 5x10...

To investigate this question, a transgenic murine model system was created by expressing a membrane-bound model antigen (OVA-HEL) under the control of the nephrin promoter specifically on glomerular podocytes (NOH mice). These cells would then be targets of adoptively transferred OVA- or HEL-specific lymphocytes.

tight proteins, including ZO‑1 and Occludin, were signicantly reduced in HFD ‑fed mice but markedly restored after nobiletin intervention, particularly in NOH mice. Improvements in the intestinal barrier and lipid metabolism associated with major histocompatibility complex class II (MHC‑II) and relevant elements were revealed after nobi‑