2019年3月1日 · Here, we identify the TERRA binding proteins NONO and SFPQ as novel regulators of RNA:DNA hybrid related telomere instability. NONO and SFPQ locate at telomeres and have a common role in...

2021年8月24日 · We found that ASXL1 phase separates in vitro and in vivo, upregulates NEAT1 expression, and enhances NONO- NEAT1 interaction, thereby promoting paraspeckle formation through the C-terminal IDR. Importantly, mutant ASXL1 that lacks IDR is unable to support paraspeckle formation and induces NONO mislocalization in the cytoplasm.

2023年3月2日 · We show by chemical proteomics that the compounds engage C145 of the RNA-binding protein NONO. Broader profiling revealed that covalent NONO ligands suppress an array of cancer-relevant genes...

2021年8月24日 · ASXL1 forms phase-separated droplets, upregulates NEAT1 expression, and increases NONO-NEAT1 interactions through the C-terminal intrinsically disordered region (IDR). In contrast, a pathogenic ASXL mutant (ASXL1-MT) lacking IDR does not support the interaction of paraspeckle components.

NONO is a multifunctional protein that acts as a “molecular scaffold” to carry out versatile biological activities in many aspects of gene regulation, cell proliferation, apoptosis, migration,...

重新引入野生型 NONO，而不是 C145S 突变体，可以恢复 NONO 破坏的细胞中的配体敏感性。 这些配体促进 NONO 在核灶中积累，并稳定 NONO-RNA 相互作用，支持可能阻止旁系同源蛋白 PSPC1 和 SFPQ 补偿作用的捕获机制。

NONO (non-POU-domain-containing octamer binding protein)是一种多功能的核蛋白质,作为人类剪切蛋白家族的一员,NONO参与多种生物学事件,如基因转录调控、前体RNA剪接、DNA解螺旋和配对、缺陷RNA核滞留、DNA损伤的修复以及肿瘤发生等过程。

2025年3月11日 · NONO conversion to Indonesian Rupiah is 1 NONO = 98,857.94 IDR. In the past 24h, the exchange rate was moving between 0 and 98,857.94 IDR. Get live price now!

2017年1月12日 · Here, we introduce an optogenetic platform that uses light to activate IDR-mediated phase transitions in living cells. We use this “optoDroplet” system to study condensed phases driven by the IDRs of various RNP body proteins, including FUS, DDX4, and HNRNPA1.

We found that ASXL1 phase separates in vitro and in vivo, upregulates NEAT1 expression, and en-hances NONO-NEAT1 interaction, thereby promoting para-speckle formation through the C-terminal IDR. Importantly, mutant ASXL1 that lacks IDR is unable to support paraspeckle formation and induces NONO mislocalization in the cytoplasm.