2015年5月21日 · quinone oxidoreductase 1 (NQO1), a cytoplasmic 2-electron reductase, is induced during oncogene-induced senescence (OIS). Depletion of NQO1 resulted in the delayed onset of senescence. In contrast, ectopic expression of NQO1 enhanced the senescence phenotype. Analysis of the mechanism underlying the …

2019年7月1日 · NAD (P)H quinone oxidoreductase 1 (NQO1) is a multi-functional protein that catalyses the reduction of quinones (and other molecules), thus playing roles in xenobiotic detoxification and redox balance, and also has roles in stabilising apoptosis regulators such as …

NQO1 is one of the two major quinone reductases in mammalian systems. It is highly inducible and plays multiple roles in cellular adaptation to stress. A prevalent polymorphic form of NQO1 results in an absence of NQO1 protein and activity so it is important to elucidate the specific cellular functions of NQO1.

2021年5月24日 · NAD (P)H:quinone oxidoreductase 1 (NQO1) has been shown to be a potential therapeutic target for various human diseases, such as cancer and neurodegenerative disorders. Recent advances in computational methods, especially network-based methods, have made it possible to identify novel compounds for a target with high efficiency and low cost.

The nociceptin opioid peptide receptor (NOP), also known as the nociceptin/orphanin FQ (N/OFQ) receptor or kappa-type 3 opioid receptor, is a protein that in humans is encoded by the OPRL1 (opioid receptor-like 1) gene. [5] .

Following the identification of the nociceptin/orphanin FQ (N/OFQ) peptide (NOP) as an endogenous ligand for the NOP receptor, ample evidence has revealed unique functional profiles of the N/OFQ-NOP receptor system. NOP receptors are expressed in key neural substrates involved in pain and reward modulation.

2015年1月1日 · Cells from the immune system express the precursor preproN/OFQ and the NOP receptor, as well as secrete N/OFQ. The activation of the N/OFQ-NOP pathway can regulate inflammatory and immune responses.

该控制器支持多相配置,峰值电流模式控制,内置强大的N沟道MOSFET驱动器和自适应死区时间控制。 开关频率可编程至1MHz,具有可选的二极管仿真模式和多种保护功能。 LM5122QMHX/NOPB由TI (德州仪器)设计生产，立创商城现货销售。 LM5122QMHX/NOPB价格参考￥10.82。 TI (德州仪器) LM5122QMHX/NOPB参数名称：功能类型：升压型；工作电压：4.5V~65V；开关频率：1MHz；工作温度：-40℃~+125℃@ (TJ)；同步整流：是；输出通道数：1；拓扑结构：升 …

伤害感受肽/孤啡肽 FQ (N/OFQ) 肽 (NOP) 受体是阿片受体超家族的成员，N/OFQ 为其内源性激动剂。 NOP 受体和 N/OFQ 在中枢和外周的广泛表达，以及它们调节多种生物功能的能力，导致制药公司根据其在疼痛、焦虑、焦虑等临床前模型中的功效，开发了 NOP 受体调节剂作为治疗剂。 抑郁症、帕金森病和药物滥用。 创伤后应激障碍 (PTSD) 和创伤性脑损伤 (TBI) 都是使人衰弱的疾病，严重影响全世界数百万人的生活质量。 创伤后应激障碍 (PTSD) 和创伤性脑损伤 (TBI) 均由 …

2013年1月1日 · This review collates the available evidence for a role of the non-classical opioid receptor NOP in regulation of airway physiology. N/OFQ has both bronchodilatory and immunomodulatory properties. N/OFQ–NOP system is a novel target worthy of investigation in airway disease. 1. N/OFQ and NOP receptor.