2024年5月27日 · Accumulating evidence indicates that the Notch signaling pathway serves as both an oncogenic factor and a tumor suppressor in various cancer types. Dysregulation of this pathway promotes...

2022年3月24日 · NOTCH signaling deeply participates in the development and homeostasis of multiple tissues and organs, the aberration of which results in cancerous and noncancerous diseases. However, recent...

More recently, unbiased genome-scale sequencing studies identified mutations in Notch genes in a broad spectrum of cancers. Remarkably, the positions, identities, and effects of these mutations are cancer-specific and reflect varied roles for Notch in different cancer contexts.

2020年12月8日 · Notch signalling is involved in many aspects of cancer biology, including angiogenesis, tumour immunity and the maintenance of cancer stem-like cells. In addition, Notch can function as an...

2017年1月24日 · Notch receptors influence cellular behavior by participating in a seemingly simple signaling pathway, but outcomes produced by Notch signaling are remarkably varied depending on signal dose and cell context.

2022年10月1日 · This review provides an overview of the roles of Notch in cancer and discusses challenges to clinical translation of Notch targeting agents as well as approaches that may overcome these hurdles.

The Notch signaling pathway, which controls multiple cell differentiation processes during the embryonic stage and adult life, is associated with carcinogenesis and disease progression. The aim of the present study was to highlight cancer ...

The Notch signaling pathway, which is highly conserved across species, is implicated in numerous aspects of cancer biology, including the cancer stem cell phenotype, tumor angiogenesis, metastasis, and tumor immune evasion [1 – 5].

2024年5月27日 · Accumulating evidence indicates that the Notch signaling pathway serves as both an oncogenic factor and a tumor suppressor in various cancer types. Dysregulation of this pathway promotes epithelial-mesenchymal transition and angiogenesis in malignancies, closely linked to cancer proliferation, invasion, and metastasis.

2015年12月1日 · Notch inhibitor alone or in combination with chemotherapeutics is clinically evaluated on some cancer. The Notch pathway is involved in cell proliferation, differentiation and survival. The Notch signaling pathway is one of the most …