
Notch 4 - Wikipedia
Neurogenic locus notch homolog 4 (Notch 4) is a protein that in humans is encoded by the NOTCH4 gene located on chromosome 6. [5] An alternative splice variant of the NOTCH4 …
NOTCH4 Gene - GeneCards | NOTC4 Protein | NOTC4 Antibody
2024年12月25日 · NOTCH4 (Notch Receptor 4) is a Protein Coding gene. Diseases associated with NOTCH4 include Schizoaffective Disorder and Schizophrenia. Among its related …
经典信号通路总结——Notch信号通路 - 知乎
Notch受体是由Notch基因编码的单跨膜蛋白,在包括人类在内的哺乳动物中发现了 4种Notch受体(Notch 1,2,3,4)。 而Notch配体也是表达于细胞表面的单跨膜蛋白,相邻细胞通过Notch …
Notch信号通路介绍(及调控基因介绍) - 知乎
Notch蛋白 (在脊椎动物中为Notch1-Notch4)是一种单通路受体,它们通过与 Delta (或Delta-like)和Jagged/Serrate家族的膜结合配体相互作用而被激活。 它们以被切割但否则完整的多 …
Notch signaling pathway: architecture, disease, and therapeutics
2022年3月24日 · NOTCH receptors undergo three cleavages and translocate into the nucleus to regulate the transcription of target genes. NOTCH signaling deeply participates in the …
华中科技大学课题组在38分的STTT发表超重磅综述,带你详解这一 …
2023年3月26日 · Notch 信号是造血、免疫细胞分化的关键调节因子之一,与多种自身免疫性疾病、肿瘤的发生和肿瘤诱导的免疫抑制有关。 Notch 信号通路本身简单,但它所调控的细胞进程 …
Notch4 reveals a novel mechanism regulating Notch signal transduction
2014年7月1日 · Notch4 is a divergent member of the Notch family of receptors that is primarily expressed in the vasculature. Its expression implies an important role for Notch4 in the …
Notch4 signaling limits regulatory T-cell-mediated tissue repair …
2021年6月8日 · In a prospective multi-country cohort of COVID-19 patients, we found that increased Notch4 expression on circulating regulatory T (Treg) cells was associated with …
Blood:北京基因组所揭示新靶点NOTCH4在人巨核细胞发育和再生中的重要作用 …
其中,首次揭示NOTCH4作为转录因子RUNX1的直接靶基因,负向调控体外巨核细胞发育;并筛选出Notch通路的小分子抑制剂,使得从多能干细胞和脐血来源的造血干祖细胞,生成巨核细 …
NOTCH4 notch receptor 4 [Homo sapiens (human)] - Gene - NCBI
Gene target information for NOTCH4 - notch receptor 4 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.
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