NOX-A12 - TME Pharma
NOX-A12 (olaptesed pegol) is an intravenously administered, PEGylated L-stereoisomer RNA aptamer that targets CXCL12 (C-X-C Chemokine Ligand 12), a key chemokine (signaling) …
Olaptesed pegol (NOX-A12) with bendamustine and rituximab: a ... - PubMed
Olaptesed pegol (NOX-A12) is a pegylated structured L-oligoribonucleotide that binds and neutralizes CXCL12, a chemokine tightly regulating the life cycle of chronic lymphocytic …
L-RNA aptamer-based CXCL12 inhibition combined with ... - Nature
2024年5月28日 · Targeting CXCL12 with the pegylated L-RNA aptamer olaptesed pegol (NOX-A12) was highly effective in an autochthonous rat brain tumor model mimicking a highly …
The Spiegelmer NOX-A12, a novel CXCL12 inhibitor, interferes …
2014年2月13日 · NOX-A12, a structured mirror-image RNA oligonucleotide that neutralizes CXCL12, interferes with CLL migration and drug resistance. NOX-A12 inhibits chemotaxis and …
Experience with CXCL12 inhibitor NOX-A12 plus pembrolizumab …
Background: NOX-A12 is an inhibitor of the chemokine CXCL12 which prevents receptor engagement and blocks the formation of chemotactic CXCL12 concentration gradients. The …
NOX-A12: mobilizing CLL away from home | Blood - American …
2014年2月13日 · Schematic overview of NOX-A12 mechanism of action in CLL. NOX-A12 detaches CXCL12 from the surface of bone marrow stromal cells (BMSCs), thereby …
The Spiegelmer Nox-A12, a Novel SDF-1 (CXCL12) Inhibitor, and …
2011年11月18日 · In summary, the CXCL12 inhibitor NOX-A12 is a novel, targeted agent for interference with CLL cell migration and homing to CXCL12-secreting stromal cells. Its effects …
NOX-A12 Plus Bevacizumab and Radiotherapy Shows Sustained …
2023年6月29日 · The addition of the CXCL12 inhibitor NOX-A12 to standard frontline therapy with radiation and bevacizumab led to an overall survival rate of 83% at a median follow-up of 15 …
Olaptesed pegol, an anti-CXCL12/SDF-1 Spiegelmer, alone and
2017年1月11日 · Olaptesed pegol (olaptesed, NOX-A12) is a pegylated l-oligoribonucleotide that binds and neutralizes CXCL12, a chemokine which signals through CXCR4 and CXCR7 …
Phase I/II study with CXCL12 inhibitor NOX-A12 and …
NOX-A12 is an inhibitor of the chemokine CXCL12 which prevents receptor engagement and blocks the formation of chemotactic CXCL12 concentration gradients.
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