Nox4: A Hydrogen Peroxide-Generating Oxygen Sensor - PMC
Critically, Nox4 has an unusually high K m for oxygen (∼18%), similar to the values of known oxygen-sensing enzymes, compared with a K m of 2–3% for Nox2, the phagocyte NADPH …
The human Nox4: gene, structure, physiological function and ...
As a key oxygen sensor, Nox4-derived H2O2 plays diverse roles in cell proliferation, migration and death. Increased expression of Nox4 in cancer has been observed, which participates in …
The NADPH oxidase 4 is a major source of hydrogen peroxide in
2019年3月5日 · We identified a source of H 2 O 2, the enzyme NADPH oxidase (NOX) 4, in isolated differentiated, in-vitro fertilisation-derived human granulosa-lutein cells (GCs), in...
Nox4 Is a Protective Reactive Oxygen Species Generating Vascular …
2012年3月27日 · Nox4 is highly expressed in the vasculature and it generates mostly H 2 O 2. Using Nox4-knockout mice, we demonstrate that Nox4-derived H 2 O 2 maintains endothelial …
Nox4: From Discovery to Pathophysiology | SpringerLink
2023年6月23日 · It is unique among Nox enzymes in its lack of required cytosolic regulatory subunits and a propensity to produce hydrogen peroxide (H 2 O 2) rather than superoxide. …
Nox4-derived H2O2 mediates endoplasmic reticulum signaling through ...
Using a ratiometric H (2)O (2) sensor targeted to different subcellular compartments, we demonstrate specific production of H (2)O (2) by the ER in response to the stressors …
Nox4：产生过氧化氢的氧气传感器,Biochemistry - X-MOL
2014年8月1日 · 我们发现大约 90% 的电子通量通过孤立的 Nox4 产生 H 2 O 2并且 10% 形成超氧化物。H的动力学机制2 O 2 的形成与一个氧分子结合的机制一致，然后在两个单电子还原步 …
NOX4 产生的 H2O2 在葡萄糖剥夺下的细胞反应过程中的关键作用 …
在本研究中，发现葡萄糖剥夺可诱导 HepG2 细胞中产生细胞内过氧化氢 (H2O2)。 N-乙酰半胱氨酸 (NAC) 是一种抗氧化试剂，可减少葡萄糖剥夺引起的细胞 H2O2 水平的增加和 AKT 磷酸化 …
Hypoxia stabilizes the H2O2‐producing oxidase Nox4 in …
2023年11月20日 · Here we show that hypoxia upregulates the Nox4 protein level and Nox4-catalyzed H 2 O 2 production without increasing the Nox4 mRNA in rat H9c2 cardiomyocytes. …
Nox4: a hydrogen peroxide-generating oxygen sensor - PubMed
2014年8月12日 · Critically, Nox4 has an unusually high Km for oxygen (∼18%), similar to the values of known oxygen-sensing enzymes, compared with a Km of 2-3% for Nox2, the …