2019年7月18日 · In this study, we focused on translationally controlled tumor protein (TCTP), a highly conserved protein that is expressed ubiquitously in mammalian tissues, including...

2021年10月21日 · Here, we investigated the role of mTORC1 in regulating TCTP protein levels, thereby modulating chemosensitivity, in human lung cancer cells and an A549 lung cancer xenograft model. The inhibition...

2022年4月19日 · Here, using the transcriptome data of patients, and immune-refractory tumor models, we identify TCTP as an immune-resistance factor that correlates with clinical outcome of anti-PD-L1 therapy and...

By employing Drosophila genetics, we demonstrate that TCTP plays a crucial role in regeneration of damaged intestinal epithelium in part by regulating protein translation. Furthermore, we elucidate an unexpected crosstalk between TCTP and 2 …

2022年10月27日 · Translationally controlled tumor protein (TCTP) is a multifunctional protein that plays a wide variety of physiological and pathological roles, including as a cytoplasmic repressor of Na,K-ATPase, an enzyme pivotal in maintaining Na + and K + ion gradients across the plasma membrane, by binding to and inhibiting Na,K-ATPase.

2020年5月6日 · Translationally controlled tumor protein (TCTP) is a conserved, multifunctional protein involved in numerous cellular processes in eukaryotes. Although the functions of TCTP have been investigated sporadically in animals, invertebrates, and plants, few lineage-specific activities of this molecule, have been reported.

2017年11月18日 · The Translational Controlled Tumour Protein TCTP (gene symbol TPT1, also called P21, P23, Q23, fortilin or histamine-releasing factor, HRF) is a highly conserved protein present in essentially all eukaryotic organisms and involved in many fundamental cell biological and disease processes.

2024年3月28日 · Since TCTP (translationally controlled tumor protein) is an EV component, we investigated whether it has a role in genotoxic stress signaling and malignant transformation. By generating a Tctp -inducible knockout mouse model (Tctp–/f–), we report that Tctp is required for genotoxic stress-induced apoptosis signaling via small EVs (sEVs).

2015年1月27日 · Translationally controlled tumor protein (TCTP) is a highly conserved multifunctional protein present in all eukaryotes, across animal and plant kingdoms. TCTP...

2018年1月1日 · To investigate the role of TCTP in EMT, the present study focuses on the association of TCTP with growth factor-induced EMT and cytoskeleton modulation. Here we propose a model illustrating the increased expression of TCTP during TGF-β1 and epithelial growth factor (EGF)-induced EMT in cancer cell lines and its effect in cytoskeleton ...