Atrial natriuretic peptide (ANP) or atrial natriuretic factor (ANF) is a natriuretic peptide hormone secreted from the cardiac atria that in humans is encoded by the NPPA gene. [5]

2024年12月25日 · NPPA (Natriuretic Peptide A) is a Protein Coding gene. Diseases associated with NPPA include Atrial Standstill 2 and Atrial Fibrillation, Familial, 6. Among its related pathways are Gene expression (Transcription) and Cardiac conduction.

2020年5月22日 · In cardiac biology, NPPA is one of the pivotal cardiac genes that led to the advent of modern research into gene regulation in the cardiovascular system.

2025年2月8日 · The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis.

2021年1月7日 · Nppa encodes ANP (atrial natriuretic peptide), whereas Nppb encodes BNP (B-type natriuretic peptide), both hormones secreted by the heart and involved in cardiac development, cardiorenal homeostasis and also implicated in …

该基因编码的蛋白质属于利钠肽家族。 利钠肽与细胞外液体积和电解质稳态的控制有关。 这种蛋白质被合成为一个大的前体 (包含一个信号肽) ，它被加工以从 N 末端释放一个与血管活性肽相似的肽、心脏舒张素和另一个从 C 末端释放钠尿利尿活性的肽。 该基因的突变与 6 型家族性房颤有关。 该基因位于 1 号染色体上利钠肽家族的另一个成员附近。 [RefSeq 提供，2015 年 10 月] The protein encoded by this gene belongs to the natriuretic peptide family.

Genetic molecular approaches have delineated of the functions of NPRA by decreasing and/or increasing Npr1 gene-copies (gene-knockout and/or gene-duplication) in mice by genetically altering protein product levels.

2015年9月10日 · Variants in the human NPPA gene, encoding the ANP precursor, are associated with hypertension, stroke, coronary artery disease, heart failure (HF) and obesity. ANP and related peptides are used as biomarkers for heart disease.

2015年9月10日 · Variants in the human NPPA gene, encoding the ANP precursor, are associated with hypertension, stroke, coronary artery disease, heart failure (HF) and obesity. ANP and related peptides are used as biomarkers for heart disease. Recombinant proteins and small molecules that enhance the ANP pathway have been developed to treat patients with HF.

2005年9月1日 · Expression of Nppa is an early and specific marker for the differentiating working myocardium of the atria and ventricles of the developing heart. Around the time of birth, ventricular Nppa expression is down-regulated, to be reactivated in response to a variety of cardiovascular disorders.