2021年1月7日 · Nppa encodes ANP (atrial natriuretic peptide), whereas Nppb encodes BNP (B-type natriuretic peptide), both hormones secreted by the heart and involved in cardiac development, cardiorenal homeostasis and also implicated in …

这些结果表明了在压力过载的刺激下NEU1会进入细胞核，入核后选择性结合GATA4，促进GATA4与心肌肥厚相关基因Nppa（ANP）、Nppb（BNP）启动子的结合，并激活它们的表达，进而诱导心肌肥厚（图2E）。

In this review, we will provide recent insights into the dynamic and complex regulation of Nppa and Nppb during heart development and hypertrophy, and the association of this gene cluster with the cardiomyocyte-intrinsic program of heart regeneration.

In this review, we will provide recent insights into the dynamic and complex regulation of Nppa and Nppb during heart development and hypertrophy, and the association of this gene cluster with the cardiomyocyte-intrinsic program of heart regeneration.

2020年5月22日 · Translation of NPPA and NPPB gives rise to preprohormones (preproANP and preproBNP, respectively) that are further processed to prohormones (proANP and proBNP) and eventually to hormones (ANP...

2020年10月27日 · ANP (atrial natriuretic peptide) and BNP (B-type natriuretic peptide), encoded by the clustered genes Nppa and Nppb, are important prognostic, diagnostic, and therapeutic proteins in cardiac disease.

这两种利钠肽激素由进化保守的旁系同源基因 Nppa 和 Nppb 编码。 这两种基因在胚胎和胎儿阶段主要由心肌表达，特别是 Nppa 表达在出生后在心室中强烈减少。

2016年4月7日 · Identification of a regulatory domain controlling the Nppa-Nppb gene cluster during heart development and stress. The paralogous genes Nppa and Nppb are organized in an evolutionarily conserved cluster and provide a valuable model for studying co-regulation and regulatory landscape organization during heart development and disease.

2021年1月8日 · Coordinated ventricular expression of <i>Nppa</i> and <i>Nppb</i> is controlled in a competitive manner by a shared super enhancer, which is also required to augment stress-induced expression and to prevent premature hypertrophy.

心肌损伤的存在是 2019 年冠状病毒病 (COVID-19) 住院患者死亡率的重要预测因素，并且有证据表明住院非幸存者 COVID-19 患者的利钠肽 B 水平升高。 该蛋白质还充当具有抗菌和抗真菌活性的抗菌肽。 该基因的突变与绝经后骨质疏松症有关。 [RefSeq 提供，2020 年 8 月] This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone.